Cxcr1 - chemokine (C-X-C motif) receptor 1 Gene

中文名称：趋化因子 (CXC 基序) 受体 1

种属: Mus musculus

同用名: Il8ra

关于 Cxcr1

功能概要

预测该基因编码的蛋白可启动趋化因子结合活性和趋化因子受体活性。预计参与多个过程，包括中性粒细胞趋化性；细胞溶质钙离子浓度的正向调节；和受体内化。预测作用于 G 蛋白偶联受体信号通路的上游或内部。预测位于质膜中。预计是膜的组成部分。预计在质膜外侧活跃。在骨髓和肺中表达。该基因的人类直系同源物与人类免疫缺陷病毒传染病有关；肾盂肾炎;和尿路感染。与人类 CXCR1（CXC 基序趋化因子受体 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable chemokine binding activity and Chemokine Receptor activity. Predicted to be involved in several processes, including neutrophil chemotaxis; positive regulation of cytosolic calcium ion concentration; and receptor internalization. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Is expressed in bone marrow and lung. Human ortholog(s) of this gene implicated in human immunodeficiency virus infectious disease; pyelonephritis; and urinary tract Infection. Orthologous to human CXCR1 (C-X-C motif Chemokine Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]