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  2. FOXD4 - forkhead box D4 Gene

FOXD4 - forkhead box D4 Gene

中文名称:叉头盒 D4

种属: Homo sapiens

同用名: FKHL9; FOXD4A; FREAC5; FREAC-5

基因 ID: 2298 | 基因类型: protein coding

关于 FOXD4

Cytogenetic location: 9p24.3 Genomic coordinates (GRCh38): 9:116,231-118,417 (from NCBI)

This gene has 1 transcript (splice variant), 58 orthologues and 42 paralogues.

功能概要

该基因编码叉头/翼状螺旋盒 (FOX) 转录因子家族的成员。 FOX 转录因子在个体发育过程中的代谢、细胞增殖和基因表达等多个过程的调节中起着关键作用。该基因的突变与复杂的表型相关,包括扩张型心肌病、强迫症和自杀倾向。[RefSeq 提供,2012 年 3 月]

This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis. Mutations in this gene are associated with a complex phenotype consisting of dilated cardiomyopathy, obsessive-compulsive disorders, and suicidality. [provided by RefSeq, Mar 2012]

FOXD4 基因产物(1)

mRNA Protein Name
NM_207305.5 NP_997188.2 forkhead box protein D4
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

FOXD4 蛋白结构

Forkhead

Forkhead: Forkhead domain (104 - 199)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 439 a.a.
蛋白主名 其他名称

forkhead box protein D4

forkhead, Drosophila, homolog-like 9

FOXD4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
FOXD4 Q12950 KRTAP12-2 Homo sapiens P59991 32296183
种属内
FOXD4 Q12950 KRTAP12-2 Homo sapiens P59991 32296183
种属内
FOXD4 Q12950 KRTAP10-6 Homo sapiens P60371 32296183
种属内
FOXD4 Q12950 KRTAP10-6 Homo sapiens P60371 32296183
种属内
FOXD4 Q12950 AKAP8L Homo sapiens Q9ULX6 32296183
种属内
FOXD4 Q12950 AKAP8L Homo sapiens Q9ULX6 32296183
种属内
FOXD4 Q12950 AKAP8L Homo sapiens Q9ULX6 32296183
种属内
FOXD4 Q12950 MDFI Homo sapiens Q99750 32296183
种属内
FOXD4 Q12950 MDFI Homo sapiens Q99750 32296183
种属内
FOXD4 Q12950 MDFI Homo sapiens Q99750 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Chromosome 9p Deletion Syndrome

Monosomy 9p

Monosomy 9p Syndrome

Alfi Syndrome

9p Syndrome

Chromosome 9p Deletion

9p Deletion

9p Monosomy

Deletion 9p

Partial Monosomy 9p

9p Deletion Syndrome

9p- Syndrome

Alfi'S Syndrome

Chromosome 9, Partial Trisomy 9p

Intellectual Developmental Disorder, Autosomal Dominant 2

MRD2

Autosomal Dominant Non-Syndromic Intellectual Disability 2

Autosomal Dominant Intellectual Developmental Disorder 2

Mental Retardation, Autosomal Dominant 2

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy

Ritscher-Schinzel Syndrome

3c Syndrome

Ccc Dysplasia

Craniocerebellocardiac Dysplasia

Cranio-Cerebello-Cardiac Dysplasia

Cerebral Palsy

Infantile Cerebral Palsy

Mixed Cerebral Palsy

Palsy Cerebral

Palsy, Cerebral

Cerebral Palsy, Mixed

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus FOXD4 MGD MGI:1347467
Rattus norvegicus FOXD4 RGD RGD:621716