2. Gene
  3. Bmp4 - bone morphogenetic protein 4 Gene

Bmp4 - bone morphogenetic protein 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: BOMPR4A

基因 ID: 25296 | 基因类型: protein coding

关于 Bmp4

功能概要

Enables growth factor activity and identical protein binding activity. Involved in several processes, including animal organ development; positive regulation of calcium ion transport; and positive regulation of cell differentiation. Acts upstream of or within positive regulation of ossification and positive regulation of transcription by RNA polymerase II. Located in cytoplasm; extracellular space; and vesicle. Biomarker of Barrett's esophagus; congenital diaphragmatic hernia; epilepsy; peptic esophagitis; and prolactinoma. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and otosclerosis. Orthologous to human BMP4 (bone morphogenetic protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Bmp4 基因产物(1)

mRNA Protein Name
NM_012827.2 NP_036959.2 bone morphogenetic protein 4 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables growth factor activity IDA
IDA: 通过直接分析推断
12475223 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16245174 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in anatomical structure regression IEP
IEP: 通过表达模式推断
12808102 RGD
involved in cardiac muscle hypertrophy in response to stress IMP
IMP: 通过突变表型推断
26873969 RGD
involved in cellular response to BMP stimulus IEP
IEP: 通过表达模式推断
9246083 RGD
involved in cellular response to dexamethasone stimulus IDA
IDA: 通过直接分析推断
17537984 RGD
involved in cellular response to mechanical stimulus IEP
IEP: 通过表达模式推断
20877159 RGD
involved in cellular response to oxidative stress IDA
IDA: 通过直接分析推断
22710965 RGD
involved in cellular response to thyroid hormone stimulus IEP
IEP: 通过表达模式推断
12395077 RGD
involved in epithelial tube branching involved in lung morphogenesis IEP
IEP: 通过表达模式推断
8769111 RGD
involved in lung lobe development IEP
IEP: 通过表达模式推断
15991191 RGD
involved in negative regulation of oligodendrocyte differentiation IMP
IMP: 通过突变表型推断
16388796 RGD
involved in ovarian follicle development IMP
IMP: 通过突变表型推断
12801979 RGD
involved in positive regulation of bone mineralization IDA
IDA: 通过直接分析推断
15352071 RGD
involved in positive regulation of branching involved in ureteric bud morphogenesis IMP
IMP: 通过突变表型推断
17537984 RGD
involved in positive regulation of calcium ion transport into cytosol IMP
IMP: 通过突变表型推断
20844246 RGD
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
17286956 RGD
involved in positive regulation of endothelial cell apoptotic process IMP
IMP: 通过突变表型推断
12808102 RGD
involved in positive regulation of hepatocyte differentiation IMP
IMP: 通过突变表型推断
19229878 RGD
involved in positive regulation of mesenchymal stem cell proliferation IMP
IMP: 通过突变表型推断
19723531 RGD
involved in positive regulation of neuron differentiation IMP
IMP: 通过突变表型推断
19287192 RGD
involved in positive regulation of neuron projection development IDA
IDA: 通过直接分析推断
23325243 RGD
involved in positive regulation of neuron projection development IMP
IMP: 通过突变表型推断
23325243 RGD
acts upstream of or within positive regulation of ossification IDA
IDA: 通过直接分析推断
7911662 RGD
involved in positive regulation of ossification IMP
IMP: 通过突变表型推断
17112416 RGD
involved in positive regulation of osteoblast differentiation IDA
IDA: 通过直接分析推断
16245174 RGD
involved in positive regulation of osteoblast differentiation IMP
IMP: 通过突变表型推断
17112416 RGD
involved in positive regulation of store-operated calcium channel activity IMP
IMP: 通过突变表型推断
20844246 RGD
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
7911662 RGD
involved in regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
19229878 RGD
involved in regulation of cell differentiation IDA
IDA: 通过直接分析推断
12514223 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
16551644 RGD
involved in response to glucocorticoid IEP
IEP: 通过表达模式推断
17537984 RGD
involved in response to mechanical stimulus IEP
IEP: 通过表达模式推断
10404008 RGD
involved in response to nitric oxide IEP
IEP: 通过表达模式推断
15991191 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
12730624 RGD
involved in response to retinoic acid IEP
IEP: 通过表达模式推断
8385738 RGD
involved in response to testosterone IEP
IEP: 通过表达模式推断
20660069 RGD
involved in retina development in camera-type eye IEP
IEP: 通过表达模式推断
17069773 RGD
involved in tongue morphogenesis IEP
IEP: 通过表达模式推断
16828469 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
18758911 RGD
located in vesicle IDA
IDA: 通过直接分析推断
18758911 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

bone morphogenetic protein 4

BMP-2B

BMP-4

bone morphogenetic protein 2B

相关产品

Pre-clinical Phase
生物活性分子 (10)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-124697 BMP signaling agonist sb4 Agonist 99.98% 否
HY-16712 LDN-214117 Inhibitor 99.54% 否
HY-18961 PD 407824 Inhibitor 99.00% 否
HY-147372 SJ000063181 Activator 98.92% 否
HY-P10710A BMP-4 acetate Inhibitor 99.30% 否
HY-P10710 BMP-4 Inhibitor / 否
HY-RS01539 BMP4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-179400 LDN-193688 Inhibitor / 否
HY-RS16511 Bmp4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22943 Bmp4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Bmp4 NCBI NCBI:652
Mus musculus Bmp4 NCBI NCBI:12159
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