ACOT11 - acyl-CoA thioesterase 11 Gene

中文名称：酰基辅酶 A 硫酯酶 11

种属: Homo sapiens

同用名: BFIT; THEA; THEM1; STARD14

基因 ID: 26027 | 基因类型: protein coding

关于 ACOT11

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:54,548,228-54,639,192 (from NCBI)

This gene has 5 transcripts (splice variants), 279 orthologues and 2 paralogues. Biased expression in kidney (RPKM 35.3), small intestine (RPKM 20.0) and 9 other tissues.

功能概要

该基因编码酰基辅酶 A 硫酯酶家族的一个成员，该家族催化活化脂肪酸转化为相应的非酯化脂肪酸和辅酶 A。小鼠同系物在棕色脂肪组织中的表达受低温诱导，并受热抑制温度。与肥胖倾向小鼠相比，在抗肥胖小鼠中发现小鼠同系物的表达水平更高，表明酰基辅酶 A 硫酯酶 11 在肥胖中的作用。可变剪接导致转录物变异。[RefSeq 提供，2010 年 11 月]

This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]

ACOT11 基因产物(2)

mRNA	Protein	Name
NM_015547.4	NP_056362.1	acyl-coenzyme A thioesterase 11 isoform 1
NM_147161.4	NP_671517.1	acyl-coenzyme A thioesterase 11 isoform 2

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables fatty acyl-CoA hydrolase activity	IDA IDA: 通过直接分析推断	22897136	GOA
enables long-chain fatty acyl-CoA hydrolase activity	IDA IDA: 通过直接分析推断	22897136	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	22897136	GOA
located in mitochondrial matrix	IDA IDA: 通过直接分析推断	22897136	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ACOT11 蛋白结构

4HBT

START

0
100
200
300
400
500
607 a.a.

蛋白主名

其他名称

acyl-coenzyme A thioesterase 11

START domain containing 14

ACOT11 抗体

目录号	产品名	应用	反应物种
HY-P89995	ACOT11 Antibody (YA9339)	WB, ICC/IF, IF-Tissue, IP, ELISA	human

关联疾病

疾病名称

别名

Leukoencephalopathy With Vanishing White Matter

Cree Leukoencephalopathy	Vanishing White Matter Disease
Ovarioleukodystrophy	Vanishing White Matter Leukodystrophy
Childhood Ataxia With Central Nervous System Hypomyelinization	Cach
Cach Syndrome	Myelinosis Centralis Diffusa
VWM	Cle
Childhood Ataxia With Central Nervous System Hypomyelination	Childhood Ataxia With Diffuse Central Nervous System Hypomyelination
Cach/Vwm	Cach/Vwm Syndrome
Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter	Cree Leukoencehalopathy
Late Infantile Cach Syndrome	Juvenile Or Adult Cach Syndrome
Congenital Or Early Infantile Cach Syndrome	Leukodystrophy With Vanishing White Matter

Multiple Acyl-Coa Dehydrogenase Deficiency

MADD	Ethylmalonic-Adipicaciduria
Ema	Glutaric Acidemia Iia
Glutaric Acidemia Iib	Ga Ii
Glutaric Acidemia Iic	Glutaric Acidemia Type 2
Glutaric Acidemia Ii	Glutaric Aciduria Ii
Electron Transfer Flavoprotein Deficiency	Glutaric Aciduria Type 2
Mad Deficiency	Glutaric Acidemia Type Ii
Glutaric Aciduria 2	Etfa Deficiency
Etfb Deficiency	Etfdh Deficiency
Multiple Acyl Coenzyme A Dehydrogenase Deficiency	Ga2
Electron Transfer Flavoprotein Ubiquinone Oxidoreductase Deficiency	Electron Transfer Flavoprotein Dehydrogenase Deficiency
Ga 2	Glutaric Acidemia 2
Glutaric Acidemia, Type 2	Glutaric Aciduria, Type 2
Mad	Multiple Fad Dehydrogenase Deficiency
Ethylmalonic Adipic Aciduria	Glutaricaciduria Ii
Glutaric Aciduria 2a	GA2A
Gaiia	Glutaricaciduria Iia
Glutaric Aciduria 2b	GA2B
Gaiib	Glutaricaciduria Iib
Glutaric Aciduria 2c	GA2C
Gaiic	Glutaricaciduria Iic
Glutaricaciduria, Type Iia	Glutaric Acidemia Type 2a
Glutaric Acidemia Type 2c	Glutaric Aciduria Iia
Glutaric Aciduria Iib	Glutaric Aciduria Iic

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00174	ACOT11 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	ACOT11	VGNC	VGNC:59518
Rattus norvegicus	ACOT11	RGD	RGD:2324815
Mus musculus	ACOT11	MGD	MGI:1913736
Canis familiaris	ACOT11	VGNC	VGNC:37516
Bos taurus	ACOT11	VGNC	VGNC:25547
Macaca mulatta	ACOT11	VGNC	VGNC:69458

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

粤ICP备2021105330号-3

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ACOT11 - acyl-CoA thioesterase 11 Gene

关于 ACOT11

功能概要

ACOT11 基因产物(2)

ACOT11 蛋白结构

ACOT11 抗体

关联疾病

直系同源

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ACOT11 - acyl-CoA thioesterase 11 Gene

关于 ACOT11

功能概要

ACOT11 基因产物(2)

ACOT11 蛋白结构

ACOT11 抗体

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

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Q

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T

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