1. Gene
  2. EHF - ETS homologous factor Gene

EHF - ETS homologous factor Gene

中文名称:ETS 同源因子

种属: Homo sapiens

同用名: ESE3; ESEJ; ESE3B

基因 ID: 26298 | 基因类型: protein coding

关于 EHF

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:34,621,093-34,663,288 (from NCBI)

This gene has 12 transcripts (splice variants), 205 orthologues and 28 paralogues. Biased expression in esophagus (RPKM 89.9), colon (RPKM 60.6) and 12 other tissues.

功能概要

该基因编码的蛋白质属于以上皮特异性表达 (ESE) 为特征的 ETS 转录因子亚家族。编码的蛋白质充当转录抑制因子,可能参与上皮细胞分化和癌变。已发现该基因的三个转录变体编码不同的亚型。[RefSeq 提供,2011 年 6 月]

This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be involved in epithelial differentiation and carcinogenesis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

EHF 基因产物(19)

mRNA Protein Name
NM_001206615.2 NP_001193544.1 ETS homologous factor isoform 3
NM_001206616.2 NP_001193545.1 ETS homologous factor isoform 1 precursor
NM_001378041.1 NP_001364970.1 ETS homologous factor isoform 2
NM_001378042.1 NP_001364971.1 ETS homologous factor isoform 2
NM_001378043.1 NP_001364972.1 ETS homologous factor isoform 2
NM_001378044.1 NP_001364973.1 ETS homologous factor isoform 2
NM_001378045.1 NP_001364974.1 ETS homologous factor isoform 2
NM_001378046.1 NP_001364975.1 ETS homologous factor isoform 2
NM_001378047.1 NP_001364976.1 ETS homologous factor isoform 2
NM_001378048.1 NP_001364977.1 ETS homologous factor isoform 3
NM_001378049.1 NP_001364978.1 ETS homologous factor isoform 4
NM_001378050.1 NP_001364979.1 ETS homologous factor isoform 4
NM_001378051.1 NP_001364980.1 ETS homologous factor isoform 4
NM_001378052.1 NP_001364981.1 ETS homologous factor isoform 5 precursor
NM_001378053.1 NP_001364982.1 ETS homologous factor isoform 6
NM_001378054.1 NP_001364983.1 ETS homologous factor isoform 7
NM_001378055.1 NP_001364984.1 ETS homologous factor isoform 8
NM_001378056.1 NP_001364985.1 ETS homologous factor isoform 9
NM_012153.6 NP_036285.2 ETS homologous factor isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
10644770 GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
10644770 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
17027647 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in epithelial cell differentiation IEP
IEP: 通过表达模式推断
10644770 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
10644770 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

EHF 蛋白结构

SAM_PNT

SAM_PNT: Sterile alpha motif (SAM)/Pointed domain (38 - 114)

Ets

Ets: Ets-domain (207 - 290)

  • 0
  • 100
  • 200
  • 300 a.a.
蛋白主名 其他名称

ETS homologous factor

ESE3 transcription factor

EHF 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
EHF Q9NZC4 KPRP Homo sapiens Q5T749 33961781
种属内
EHF Q9NZC4 KPRP Homo sapiens Q5T749 28514442
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Allergic Urticaria
Infiltrative Basal Cell Carcinoma

Skin Infiltrating Basal Cell Carcinoma

Milk Allergy

Milk Allergic Reaction

Milk Hypersensitivity

Allergy Milk

Cow Milk Allergy

Bos Taurus Milk Allergy

Cow'S Milk Protein Sensitivity

Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris EHF VGNC VGNC:40249
Felis catus EHF VGNC VGNC:102879
Macaca mulatta EHF VGNC VGNC:72178
Mus musculus EHF MGD MGI:1270840
Bos taurus EHF VGNC VGNC:28375
Rattus norvegicus EHF RGD RGD:1310282