2. Gene
  3. Pdx1 - pancreatic and duodenal homeobox 1 Gene

Pdx1 - pancreatic and duodenal homeobox 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Idx1; Ipf1; Stf1

基因 ID: 29535 | 基因类型: protein coding

关于 Pdx1

功能概要

Enables DNA-binding transcription factor activity; promoter-specific chromatin binding activity; and sequence-specific DNA binding activity. Contributes to DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including animal organ development; detection of glucose; and regulation of transcription, DNA-templated. Located in nucleus. Colocalizes with cytoplasm. Biomarker of acute necrotizing pancreatitis; hyperglycemia; placental insufficiency; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in cerebral infarction; hyperglycemia; maturity-onset diabetes of the young type 4; pancreatic agenesis; and type 2 diabetes mellitus. Orthologous to human PDX1 (pancreatic and duodenal homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Pdx1 基因产物(1)

mRNA Protein Name
NM_022852.4 NP_074043.4 pancreas/duodenum homeobox protein 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity IMP
IMP: 通过突变表型推断
15151993 RGD
contributes to DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
10094480 RGD
enables promoter-specific chromatin binding IDA
IDA: 通过直接分析推断
19380737 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
15001545 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
8524276 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
10094480 RGD
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
10094480 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA-templated transcription IMP
IMP: 通过突变表型推断
15151993 RGD
involved in animal organ regeneration IEP
IEP: 通过表达模式推断
17690043 RGD
involved in cell differentiation IMP
IMP: 通过突变表型推断
11309388 RGD
involved in glucose mediated signaling pathway IDA
IDA: 通过直接分析推断
21108535 RGD
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
17641871 RGD
involved in pancreas development IEP
IEP: 通过表达模式推断
18778483 RGD
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
18253862 RGD
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
11158595 RGD
involved in positive regulation of insulin secretion IMP
IMP: 通过突变表型推断
18439098 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
10094480 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
21108535 RGD
involved in regulation of gene expression IMP
IMP: 通过突变表型推断
10802714 RGD
involved in response to L-leucine IEP
IEP: 通过表达模式推断
19438972 RGD
involved in response to alkaloid IEP
IEP: 通过表达模式推断
15448089 RGD
involved in response to chlorate IEP
IEP: 通过表达模式推断
17221210 RGD
involved in response to cytokine IEP
IEP: 通过表达模式推断
16948396 RGD
involved in response to fatty acid IEP
IEP: 通过表达模式推断
17181874 RGD
involved in response to glucocorticoid IEP
IEP: 通过表达模式推断
15331541 RGD
involved in response to glucose IEP
IEP: 通过表达模式推断
18230696 RGD
involved in response to glucose IMP
IMP: 通过突变表型推断
15148392 RGD
involved in response to iron(II) ion IEP
IEP: 通过表达模式推断
16081762 RGD
involved in response to lipid IEP
IEP: 通过表达模式推断
17991758 RGD
involved in response to nicotine IEP
IEP: 通过表达模式推断
18687784 RGD
involved in response to nutrient levels IEP
IEP: 通过表达模式推断
17882398 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
19438972 RGD
involved in response to vitamin IEP
IEP: 通过表达模式推断
11833042 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
17991720 RGD
involved in smoothened signaling pathway IMP
IMP: 通过突变表型推断
11181516 RGD
involved in stem cell differentiation IEP
IEP: 通过表达模式推断
19382247 RGD
involved in stem cell differentiation IMP
IMP: 通过突变表型推断
18253862 RGD
involved in transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
15151993 RGD
involved in transdifferentiation IEP
IEP: 通过表达模式推断
10952464 RGD
involved in type B pancreatic cell differentiation IMP
IMP: 通过突变表型推断
21108535 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

pancreas/duodenum homeobox protein 1

IDX-1

IPF-1

Insulin promoter factor 1

STF-1

insulin promotor factor 1

islet/duodenum homeobox-1

pancreatic and duodenal homeobox gene 1

somatostatin transactivating factor 1

Pdx1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Pdx1 P52947 Psmd9 Rattus norvegicus Q9WTV5
Y2H
15885879
种属内
Pdx1 P52947 Psmd9 Rattus norvegicus Q9WTV5
Pull Down
15885879
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-171454 DA-1241 99.18% Phase 2
Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-19694 BRD7552 Activator 99.81% 否
HY-N0777 Isorhamnetin-3-O-glucoside 99.96% 否
HY-RS10264 PDHX Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS10295 PDX1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-W1130459 (R)-C12-200 / 否
HY-174547 Human PDX1 mRNA / 否
HY-RS20792 Pdx1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21404 Pdhx Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27306 Pdx1 Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P991294 MGTA-117 Antibody / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pdx1 NCBI NCBI:3651
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z