HTN1 - histatin 1 Gene

中文名称：组蛋白 1

种属: Homo sapiens

同用名: HIS1

基因 ID: 3346 | 基因类型: protein coding

关于 HTN1

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:70,050,438-70,058,848 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 15 orthologues and 2 paralogues. Restricted expression toward salivary gland (RPKM 17545.5).

功能概要

该基因编码富含组氨酸的小阳离子蛋白组蛋白家族的成员。它们起到抗菌肽的作用，是先天免疫系统的重要组成部分。组蛋白存在于唾液中并表现出抗菌、抗真菌活性和伤口愈合功能。[RefSeq 提供，2014 年 8 月]

This gene encodes a member of the histatin family of small, histidine-rich, cationic proteins. They function as antimicrobial peptides and are important components of the innate immune system. Histatins are found in saliva and exhibit Antibacterial, Antifungal activities and function in wound healing. [provided by RefSeq, Aug 2014]

HTN1 基因产物(2)

mRNA	Protein	Name
NM_001368990.1	NP_001355919.1	histatin-1 isoform 2 precursor
NM_002159.4	NP_002150.1	histatin-1 isoform 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16203048	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: 通过直接分析推断	3286634	GOA
involved in killing of cells of another organism	IDA IDA: 通过直接分析推断	3286634	GOA
involved in positive regulation of cell-cell adhesion	IDA IDA: 通过直接分析推断	25903106	GOA
involved in positive regulation of metabolic process	IDA IDA: 通过直接分析推断	28542418	GOA
involved in positive regulation of metabolic process	IMP IMP: 通过突变表型推断	32225006	GOA
involved in positive regulation of substrate adhesion-dependent cell spreading	IDA IDA: 通过直接分析推断	25903106	GOA
involved in positive regulation of vascular wound healing	IDA IDA: 通过直接分析推断	28751526	GOA
involved in positive regulation of wound healing	IDA IDA: 通过直接分析推断	18650243	GOA
involved in positive regulation of wound healing, spreading of epidermal cells	IDA IDA: 通过直接分析推断	28751526	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in endoplasmic reticulum	IDA IDA: 通过直接分析推断	34233061	GOA
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	32225006	GOA
is active in endoplasmic reticulum	IMP IMP: 通过突变表型推断	32225006	GOA
located in extracellular space	IDA IDA: 通过直接分析推断	3286634	GOA
is active in mitochondrion	IDA IDA: 通过直接分析推断	35970844	GOA
located in mitochondrion	IDA IDA: 通过直接分析推断	32225006	GOA
is active in mitochondrion	IMP IMP: 通过突变表型推断	32225006	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

histatin-1

PPB

HTN1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	HTN1	P15515	MUC7	Homo sapiens	Q8TAX7	Y2H	16203048
种属内	HTN1	P15515	MUC7	Homo sapiens	Q8TAX7	Far-WB	16203048

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hypertension And Brachydactyly Syndrome

Brachydactyly With Hypertension	Bilginturan Syndrome
HTNB	Brachydactyly-Arterial Hypertension Syndrome
Brachydactyly, Type E, With Short Stature And Hypertension	Bilginturan Brachydactyly
Brachydactyly Type E With Short Stature And Hypertension	Type E Brachydactyly With Short Stature And Hypertension
Brachydactyly Type E, With Short Stature And Hypertension	Hypertension With Brachydactyly

Candida Glabrata

Torulopsis Glabrata

Dental Caries

Dental Caries Extending Into Pulp	Dental Caries Of Smooth Surface
Dental Caries Pit And Fissure	Smooth Surface Dental Caries
Dental Decay	Carious Teeth
Dental Cavity	Saprodontia
Teeth Decayed	Tooth Caries
Tooth Decay

Acute Apical Periodontitis

Acute Apical Periodontitis Of Pulpal Origin	Acute Apical Periodontitis Nos
Aap - [Acute Apical Periodontitis]

Renal Artery Atheroma

Atherosclerosis Of Renal Artery	Renal Atherosclerosis
Atherosclerotic Renal Disease	Ras - [Renal Artery Stenosis]
Renal Arterial Arteriosclerosis	Renal Arterial Arteriosclerotic Disease
Renal Arterial Stricture	Renal Artery Stricture
Renal Artery Stenosis Of Unknown Cause	Renal Artery Stenosis Due To Atherosclerosis
Renal Artery Stenosis	Renal Artery Arteriosclerotic Disease
Renal Artery Arteriosclerosis

Short-Rib Thoracic Dysplasia 2 With Or Without Polydactyly

Asphyxiating Thoracic Dystrophy 2	SRTD2
Atd2	Jatd
Jeune Asphyxiating Thoracic Dystrophy	Jeune Syndrome 2

Renal Artery Disease

Renal Vascular Disease	Vascular Disorder Of Kidney
Renal Vascular Disorder

Sialolithiasis

Sialolith	Stone Of Salivary Gland Or Duct
Salivary Gland Calculi	Salivary Gland Stone
Calculus Of Salivary Gland Or Duct	Calculus Of Salivary Gland
Salivary Calculus	Salivary Gland Calculus
Salivary Stone	Salivary Duct Calculi
Sialodocholithiasis

Wrinkly Skin Syndrome

WSS	Wrinkled Skin Syndrome

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

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HTN1 - histatin 1 Gene

关于 HTN1

功能概要

HTN1 基因产物(2)

HTN1 蛋白互作信息

关联疾病

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HTN1 - histatin 1 Gene

关于 HTN1

功能概要

HTN1 基因产物(2)

HTN1 蛋白互作信息

关联疾病

相关产品

热门区域

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B

C

F

G

H

J

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Q

S

T

X

Y

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