MSGN1 - mesogenin 1 Gene

中文名称：介晶素 1

种属: Homo sapiens

同用名: MSOG; pMsgn1

基因 ID: 343930 | 基因类型: protein coding

关于 MSGN1

Cytogenetic location: 2p24.2 Genomic coordinates (GRCh38): 2:17,816,460-17,817,798 (from NCBI)

This gene has 1 transcript (splice variant), 176 orthologues and 2 paralogues.

功能概要

启用序列特异性双链 DNA 结合活性。预计通过 RNA 聚合酶 II 参与中胚层形成和转录调控。预计在片段规范和体细胞发生的上游或内部起作用。预测是染色质的一部分。预计活跃于核心。 [由基因组资源联盟提供，2022 年 4 月]

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in mesoderm formation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within segment specification and somitogenesis. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

MSGN1 基因产物(1)

mRNA	Protein	Name
NM_001105569.3	NP_001099039.1	mesogenin-1

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MSGN1 蛋白结构

HLH

0
100
193 a.a.

蛋白主名

其他名称

mesogenin-1

pMesogenin1

MSGN1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MSGN1	A6NI15	ZWINT	Homo sapiens	O95229	Y2H Prey Pooling	32296183
种属内	MSGN1	A6NI15	ZWINT	Homo sapiens	O95229	Validated Y2H	32296183
种属内	MSGN1	A6NI15	ZWINT	Homo sapiens	O95229	Y2H Array	32296183
种属内	MSGN1	A6NI15	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Prey Pooling	32296183
种属内	MSGN1	A6NI15	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Array	32296183
种属内	MSGN1	A6NI15	NECAB2	Homo sapiens	Q7Z6G3-2	Validated Y2H	32296183
种属内	MSGN1	A6NI15	MAGEA6	Homo sapiens	P43360	Y2H Prey Pooling	32296183
种属内	MSGN1	A6NI15	MAGEA6	Homo sapiens	P43360	Validated Y2H	32296183
种属内	MSGN1	A6NI15	MAGEA6	Homo sapiens	P43360	Y2H Array	32296183
种属内	MSGN1	A6NI15	BRAT1	Homo sapiens	Q6PJG6	Validated Y2H	32296183
种属内	MSGN1	A6NI15	BRAT1	Homo sapiens	Q6PJG6	Y2H Array	32296183
种属内	MSGN1	A6NI15	BRAT1	Homo sapiens	Q6PJG6	Y2H Prey Pooling	32296183
种属内	MSGN1	A6NI15	TEPSIN	Homo sapiens	Q96N21	Validated Y2H	32296183
种属内	MSGN1	A6NI15	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
种属内	MSGN1	A6NI15	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
种属内	MSGN1	A6NI15	CTAG1A	Homo sapiens	P78358	Y2H Prey Pooling	32296183
种属内	MSGN1	A6NI15	CTAG1A	Homo sapiens	P78358	Validated Y2H	32296183
种属内	MSGN1	A6NI15	CTAG1A	Homo sapiens	P78358	Y2H Array	32296183
种属内	MSGN1	A6NI15	TCF12	Homo sapiens	Q99081-3	Y2H Prey Pooling	32296183
种属内	MSGN1	A6NI15	TCF12	Homo sapiens	Q99081-3	Validated Y2H	32296183
种属内	MSGN1	A6NI15	TCF12	Homo sapiens	Q99081-3	Y2H Array	32296183
种属内	MSGN1	A6NI15	AP1B1	Homo sapiens	Q10567-3	Y2H Array	32296183
种属内	MSGN1	A6NI15	AP1B1	Homo sapiens	Q10567-3	Y2H Prey Pooling	32296183
种属内	MSGN1	A6NI15	AP1B1	Homo sapiens	Q10567-3	Validated Y2H	32296183
种属内	MSGN1	A6NI15	ZMYND12	Homo sapiens	Q9H0C1	Y2H Array	32296183
种属内	MSGN1	A6NI15	ZMYND12	Homo sapiens	Q9H0C1	Y2H Prey Pooling	32296183
种属内	MSGN1	A6NI15	ZMYND12	Homo sapiens	Q9H0C1	Validated Y2H	32296183
种属内	MSGN1	A6NI15	TEX12	Homo sapiens	Q9BXU0	Validated Y2H	32296183
种属内	MSGN1	A6NI15	TEX12	Homo sapiens	Q9BXU0	Y2H Array	32296183
种属内	MSGN1	A6NI15	TEX12	Homo sapiens	Q9BXU0	Y2H Prey Pooling	32296183
种属内	MSGN1	A6NI15	ID1	Homo sapiens	P41134	Y2H Prey Pooling	32296183
种属内	MSGN1	A6NI15	ID1	Homo sapiens	P41134	Validated Y2H	32296183
种属内	MSGN1	A6NI15	ID1	Homo sapiens	P41134	Y2H Array	32296183
种属内	MSGN1	A6NI15	MYL9	Homo sapiens	P24844-2	Y2H Prey Pooling	32296183
种属内	MSGN1	A6NI15	MYL9	Homo sapiens	P24844-2	Y2H Array	32296183
种属内	MSGN1	A6NI15	MYL9	Homo sapiens	P24844-2	Validated Y2H	32296183
种属内	MSGN1	A6NI15	TCF4	Homo sapiens	P15884-3	Validated Y2H	32296183
种属内	MSGN1	A6NI15	TCF4	Homo sapiens	P15884-3	Y2H Array	32296183
种属内	MSGN1	A6NI15	TCF4	Homo sapiens	P15884-3	Y2H Prey Pooling	32296183
种属内	MSGN1	A6NI15	ID3	Homo sapiens	Q02535	Y2H Prey Pooling	32296183
种属内	MSGN1	A6NI15	ID3	Homo sapiens	Q02535	Y2H Array	32296183
种属内	MSGN1	A6NI15	ID3	Homo sapiens	Q02535	Validated Y2H	32296183
种属内	MSGN1	A6NI15	MYF5	Homo sapiens	P13349	Y2H Array	32296183
种属内	MSGN1	A6NI15	MYF5	Homo sapiens	P13349	Y2H Prey Pooling	32296183
种属内	MSGN1	A6NI15	MYF5	Homo sapiens	P13349	Validated Y2H	32296183
种属内	MSGN1	A6NI15	OST4	Homo sapiens	P0C6T2	Validated Y2H	32296183
种属内	MSGN1	A6NI15	OST4	Homo sapiens	P0C6T2	Y2H Prey Pooling	32296183
种属内	MSGN1	A6NI15	OST4	Homo sapiens	P0C6T2	Y2H Array	32296183
种属内	MSGN1	A6NI15	CCDC172	Homo sapiens	P0C7W6	Validated Y2H	32296183
种属内	MSGN1	A6NI15	CCDC172	Homo sapiens	P0C7W6	Y2H Array	32296183
种属内	MSGN1	A6NI15	CCDC172	Homo sapiens	P0C7W6	Y2H Prey Pooling	32296183
种属内	MSGN1	A6NI15	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	32296183
种属内	MSGN1	A6NI15	TRAF1	Homo sapiens	Q13077	Validated Y2H	32296183
种属内	MSGN1	A6NI15	TRAF1	Homo sapiens	Q13077	Y2H Array	32296183
种属内	MSGN1	A6NI15	DNALI1	Homo sapiens	O14645	Y2H Prey Pooling	32296183
种属内	MSGN1	A6NI15	DNALI1	Homo sapiens	O14645	Y2H Array	32296183
种属内	MSGN1	A6NI15	DNALI1	Homo sapiens	O14645	Validated Y2H	32296183
种属内	MSGN1	A6NI15	EXOC7	Homo sapiens	Q9UPT5-1	Validated Y2H	32296183
种属内	MSGN1	A6NI15	ITGB3BP	Homo sapiens	Q13352	Validated Y2H	32296183
种属内	MSGN1	A6NI15	ITGB3BP	Homo sapiens	Q13352	Y2H Array	32296183
种属内	MSGN1	A6NI15	ITGB3BP	Homo sapiens	Q13352	Y2H Prey Pooling	32296183
种属内	MSGN1	A6NI15	HAP1	Homo sapiens	P54257	Y2H Prey Pooling	32296183
种属内	MSGN1	A6NI15	HAP1	Homo sapiens	P54257	Y2H Array	32296183
种属内	MSGN1	A6NI15	HAP1	Homo sapiens	P54257	Validated Y2H	32296183
种属内	MSGN1	A6NI15	ID2	Homo sapiens	Q02363	Y2H Prey Pooling	32296183
种属内	MSGN1	A6NI15	ID2	Homo sapiens	Q02363	Validated Y2H	32296183
种属内	MSGN1	A6NI15	ID2	Homo sapiens	Q02363	Y2H Array	32296183
种属内	MSGN1	A6NI15	LDOC1	Homo sapiens	O95751	Y2H Prey Pooling	32296183
种属内	MSGN1	A6NI15	LDOC1	Homo sapiens	O95751	Validated Y2H	32296183
种属内	MSGN1	A6NI15	LDOC1	Homo sapiens	O95751	Y2H Array	32296183
种属内	MSGN1	A6NI15	SERTAD3	Homo sapiens	Q9UJW9	Y2H Array	32296183
种属内	MSGN1	A6NI15	SERTAD3	Homo sapiens	Q9UJW9	Y2H Prey Pooling	32296183
种属内	MSGN1	A6NI15	SERTAD3	Homo sapiens	Q9UJW9	Validated Y2H	32296183
种属内	MSGN1	A6NI15	TTC23L	Homo sapiens	Q6PF05	Y2H Prey Pooling	32296183
种属内	MSGN1	A6NI15	TTC23L	Homo sapiens	Q6PF05	Validated Y2H	32296183
种属内	MSGN1	A6NI15	TTC23L	Homo sapiens	Q6PF05	Y2H Array	32296183
种属内	MSGN1	A6NI15	IGFBP6	Homo sapiens	P24592	Validated Y2H	32296183
种属内	MSGN1	A6NI15	IGFBP6	Homo sapiens	P24592	Y2H Array	32296183
种属内	MSGN1	A6NI15	IGFBP6	Homo sapiens	P24592	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Spondylocostal Dysostosis 4, Autosomal Recessive

SCDO4	Spondylocostal Dysostosis 4
Autosomal Recessive Spondylocostal Dysostosis 4	Doid:0112364
Dysostosis, Spondylocostal, Autosomal Recessive, Type 4

Spondylocostal Dysostosis 1, Autosomal Recessive

Jarcho-Levin Syndrome	SCDO1
Vertebral Anomalies	Spondylothoracic Dysplasia
Costovertebral Dysplasia	Spondylothoracic Dysostosis
Spondylocostal Dysostosis 1	Autosomal Recessive Spondylocostal Dysostosis 1
Spondylocostal Dysostosis, Autosomal Recessive, 1	Doid:0112365
Dysostosis, Spondylocostal, Autosomal Recessive, Type 1

Spondylocostal Dysostosis

Jarcho-Levin Syndrome	Costovertebral Dysplasia
Spondylothoracic Dysostosis	Spondylothoracic Dysplasia
Scdo	Dysostosis, Spondylocostal

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08708	MSGN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	MSGN1	VGNC	VGNC:74771
Bos taurus	MSGN1	VGNC	VGNC:31692
Mus musculus	MSGN1	MGD	MGI:1860483
Rattus norvegicus	MSGN1	RGD	RGD:1587516
Canis familiaris	MSGN1	VGNC	VGNC:43437

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