2. Gene
  3. DND1 - DND microRNA-mediated repression inhibitor 1 Gene

DND1 - DND microRNA-mediated repression inhibitor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：DND microRNA 介导的抑制抑制因子 1

种属: Homo sapiens

同用名: RBMS4

基因 ID: 373863 | 基因类型: protein coding

关于 DND1

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:140,670,794-140,673,576 (from NCBI)

This gene has 1 transcript (splice variant), 204 orthologues and 36 paralogues. Ubiquitous expression in testis (RPKM 7.3), colon (RPKM 6.1) and 25 other tissues.

功能概要

该基因编码的蛋白质可与 mRNA 的 MicroRNA 靶向序列结合，从而抑制 MicroRNA 介导的抑制。该基因的表达减少与舌鳞状细胞癌有关。该基因的两个假基因位于 17 号染色体的长臂上。[RefSeq 提供，2010 年 12 月]

This gene encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma. Two pseudogenes of this gene are located on the long arm of chromosome 17. [provided by RefSeq, Dec 2010]

DND1 基因产物(1)

mRNA Protein Name
NM_194249.3 NP_919225.1 dead end protein homolog 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables mRNA 3'-UTR binding IDA
IDA: 通过直接分析推断
18155131 GOA
NOT enables miRNA binding IDA
IDA: 通过直接分析推断
18155131 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in 3'-UTR-mediated mRNA destabilization IDA
IDA: 通过直接分析推断
28297718 GOA
involved in negative regulation of miRNA-mediated gene silencing IDA
IDA: 通过直接分析推断
18155131 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
18155131 GOA
located in nucleus IDA
IDA: 通过直接分析推断
18155131 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DND1 蛋白结构

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (60 - 123)

DND1_DSRM

DND1_DSRM: double strand RNA binding domain from DEAD END PROTEIN 1 (254 - 332)

  • 0
  • 100
  • 200
  • 300
  • 353 a.a.
蛋白主名 其他名称

dead end protein homolog 1

RNA-binding motif, single-stranded-interacting protein 4

DND1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DND1 Q8IYX4 RBPMS2 Homo sapiens Q6ZRY4
Y2H Prey Pooling
32296183
种属内
DND1 Q8IYX4 RBPMS2 Homo sapiens Q6ZRY4
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Tongue Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Tongue
Pharynx Squamous Cell Carcinoma
Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility
Testicular Disease

Testicular Dysfunction

Testicular Diseases

Disorder Of Testis

Testis Disorder

Testicular Disorders
Spermatocytoma

Spermatocytic Seminoma
Testicular Cancer

Testis Cancer

Testicular Carcinoma

Testicular Neoplasms

Malignant Neoplasm Of Testis

Childhood Neoplasm Of The Testis

Neoplasm Of Testis

Pediatric Testicular Neoplasm

Testicular Tumor

Testis Neoplasm

Testicular Tumors

Testicular Neoplasm

Testicular Malignant Germ Cell Tumor

Childhood Testicular Neoplasm

Carcinoma Of The Testis

Cancer Of Testis

Malignant Neoplasm Of Testis, Nos

Malignant Neoplasm Of Testis, Unspecified

Malignant Tumour Of Testis

Testicle Cancer

Primary Malignant Neoplasm Of Testis
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03899 DND1 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus DND1 VGNC VGNC:28138
Rattus norvegicus DND1 RGD RGD:1583648
Mus musculus DND1 MGD MGI:2447763
Macaca mulatta DND1 VGNC VGNC:110471
Canis familiaris DND1 VGNC VGNC:40028
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