1. Gene
  2. MARCKS - myristoylated alanine rich protein kinase C substrate Gene

MARCKS - myristoylated alanine rich protein kinase C substrate Gene

中文名称:肉豆蔻酰化富丙氨酸的蛋白激酶 C 底物

种属: Homo sapiens

同用名: MACS; 80K-L; PKCSL; PRKCSL

基因 ID: 4082 | 基因类型: protein coding

关于 MARCKS

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:113,857,345-113,863,475 (from NCBI)

This gene has 1 transcript (splice variant), 214 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 86.0), colon (RPKM 50.6) and 25 other tissues.

功能概要

该基因编码的蛋白质是蛋白激酶 C 的底物。它定位于质膜,是一种肌动蛋白丝交联蛋白。蛋白激酶 C 的磷酸化或与钙-钙调蛋白的结合会抑制其与肌动蛋白和质膜的结合,从而导致其存在于细胞质中。该蛋白质被认为参与细胞运动、吞噬作用、膜运输和有丝分裂发生。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008]

MARCKS 基因产物(1)

mRNA Protein Name
NM_002356.7 NP_002347.5 myristoylated alanine-rich C-kinase substrate

MARCKS 蛋白结构

MARCKS

MARCKS: MARCKS family (2 - 329)

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  • 332 a.a.
蛋白主名 其他名称

myristoylated alanine-rich C-kinase substrate

myristoylated alanine-rich protein kinase C substrate (MARCKS, 80K-L)

关联疾病

疾病名称 别名
Spinocerebellar Ataxia 14

Spinocerebellar Ataxia Type 14

SCA14

Ataxia, Spinocerebellar, Type 14

Borna Disease

Enzootic Encephalomyelitis

Anencephaly

Aprosencephaly

Anencephalus

Congenital Absence Of Brain

Absence Of A Large Part Of The Brain And The Skull

Anencephalia

Anencephalic Monster

Brain Absence

Brain Agenesis

Brain Aplasia

Absent Brain

Anencephalic

Congenital Absence Of Cerebrum

Congenital Hemicrania

Incomplete Anencephaly

Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2

Neural Tube Defects

Spina Bifida

Neural Tube Defect

NTD

Neural Tube Defects, Susceptibility To

Spinal Dysraphism

Spina Bifida, Susceptibility To

Rachischisis

Cleft Spine

Open Spine

Hydrocele Spinalis

Neural Tube Defect Nos

Sb - [Spina Bifida]

Spinal Hernia Nos

Spinal Fissure Nos

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta MARCKS VGNC VGNC:74639
Rattus norvegicus MARCKS RGD RGD:3028
Felis catus MARCKS VGNC VGNC:102456
Mus musculus MARCKS MGD MGI:96907
Bos taurus MARCKS VGNC VGNC:31244