2. Gene
  3. NPTX2 - neuronal pentraxin 2 Gene

NPTX2 - neuronal pentraxin 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：神经元五聚蛋白 2

种属: Homo sapiens

同用名: NP2; NARP; NP-II

基因 ID: 4885 | 基因类型: protein coding

关于 NPTX2

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:98,617,285-98,629,869 (from NCBI)

This gene has 2 transcripts (splice variants), 274 orthologues and 5 paralogues. Biased expression in brain (RPKM 31.6), testis (RPKM 20.6) and 4 other tissues.

功能概要

该基因编码神经元 petraxins 家族的成员，与 C 反应蛋白相关的突触蛋白。这种蛋白质参与兴奋性突触的形成。它还在 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) 型谷氨酸受体聚集在已建立的突触处发挥作用，导致多巴胺能神经细胞的非凋亡性细胞死亡。该基因在帕金森病 (PD) 组织中的上调表明该蛋白可能参与 PD 的病理学。[RefSeq 提供，2009 年 2 月]

This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD. [provided by RefSeq, Feb 2009]

NPTX2 基因产物(1)

mRNA Protein Name
NM_002523.3 NP_002514.1 neuronal pentraxin-2 precursor
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
30833544 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
27986928 GOA
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
27986928 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NPTX2 蛋白结构

Pentaxin

Pentaxin: Pentaxin family (233 - 416)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 431 a.a.
蛋白主名 其他名称

neuronal pentraxin-2

apexin

NPTX2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NPTX2 P47972 FZD6 Homo sapiens O60353
Anti Bait CoIP
30833544
种属内
NPTX2 P47972 FZD6 Homo sapiens O60353
Anti Tag CoIP
30833544
种属内
NPTX2 P47972 FZD6 Homo sapiens O60353
IF
30833544
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Narcolepsy

Paroxysmal Sleep

Gelineau Syndrome

Narcoleptic Syndrome

Narcolepsy-Cataplexy Syndrome

Cataplexy And Narcolepsy

Narcolepsy, Without Cataplexy

Gelineau'S Syndrome

Narcolepsy With Or Without Cataplexy

Narcolepsy Nos
Diabetes Insipidus, Neurohypophyseal

Neurohypophyseal Diabetes Insipidus

Cdi

Pituitary Diabetes Insipidus

Vasopressin Defective Diabetes Insipidus

Vasopressin Deficiency

Central Diabetes Insipidus

Diabetes Insipidus, Neurogenic

Diabetes Insipidus, Primary Central

Diabetes Insipidus, Cranial Type

Diabetes Insipidus Secondary To Vasopressin Deficiency

Diabetes Insipidus, Central

Diabetes Insipidus, Pituitary

NDI

Diabetes Insipidus Cranial Type

Neurogenic Diabetes Insipidus

Primary Central Diabetes Insipidus
Diabetes Insipidus
Dipsogenic Diabetes Insipidus

Primary Polydipsia

Doid:0081058

Psychogenic Polydipsia
Central Diabetes Insipidus

Neurogenic Diabetes Insipidus

Diabetes Insipidus Cranial Type

Diabetes Insipidus Neurogenic

Diabetes Insipidus Neurohypophyseal

Neurohypophyseal Diabetes Insipidus

Pituitary Diabetes Insipidus

Cdi

Doid:0081055

Diabetes Insipidus

Di - [Diabetes Insipidus]

Adh - [Antidiuretic Hormone Secretion] Deficiency

Diabetes Mellitus Insipidus

Familial Diabetes Insipidus

Antidiuretic Hormone Hyposecretion

Vasopressin Deficiency Syndrome

Primary Central Diabetes Insipidus

Vasopressin Deficiency

Vasopressin Hyposecretion

Diabetes Insipidus Secondary To Vasopressin Deficiency
Gestational Diabetes Insipidus

Transient Diabetes Insipidus Of Pregnancy

Diabetes Insipidus Gestational

Gestagenic Diabetes Insipidus

Doid:0081057
Frontotemporal Dementia

Pallidopontonigral Degeneration

Frontotemporal Lobar Degeneration

Semantic Dementia

FTD

Frontotemporal Lobe Dementia

Multiple System Tauopathy With Presenile Dementia

Dementia, Frontotemporal

Frontotemporal Dementia With Parkinsonism

Mstd

Frontotemporal Lobar Degeneration With Tau Inclusions

Ftld With Tau Inclusions

Dementia, Frontotemporal, With Parkinsonism

Fldem

Ftdp17

Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

Ddpac

Wilhelmsen-Lynch Disease

Wld

Ppnd

Dementia, Frontotemporal, With Or Without Parkinsonism

Semantic Primary Progressive Aphasia

Semantic Variant Ppa

Wilhemsen-Lynch Disease

Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

Ftd-Als

Ftld

Pick Complex

Pick Disease Of The Brain

Frontotemporal Dementia With Parkinsonism-17

Grn-Related Frontotemporal Dementia

Frontotemporal Dementia With Motor Neuron Disease

Dementia In Fronto-Temporal Lobar Degeneration

Ftd - [Frontotemporal Dementia]

Temple Dementia

Frontal Lobe Dementia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09506 NPTX2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20456 Nptx2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26965 Nptx2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris NPTX2 VGNC VGNC:43934
Bos taurus NPTX2 VGNC VGNC:32219
Macaca mulatta NPTX2 VGNC VGNC:75392
Rattus norvegicus NPTX2 RGD RGD:1309447
Mus musculus NPTX2 MGD MGI:1858209
Felis catus NPTX2 VGNC VGNC:68537
Others NPTX2 NCBI
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