1. Gene
  2. Polg2 - polymerase (DNA directed), gamma 2, accessory subunit Gene

Polg2 - polymerase (DNA directed), gamma 2, accessory subunit Gene

种属: Mus musculus

同用名: p55; mtPolB; polG-beta

基因 ID: 50776 | 基因类型: protein coding

关于 Polg2

功能概要

Enables DNA-directed DNA Polymerase activity and identical protein binding activity. Acts upstream of or within in utero embryonic development; mitochondrion organization; and respiratory electron transport chain. Located in mitochondrion. Is expressed in early conceptus and secondary oocyte. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 4 and mitochondrial DNA depletion syndrome. Orthologous to human POLG2 (DNA Polymerase gamma 2, accessory subunit). [provided by Alliance of Genome Resources, Apr 2022]

Polg2 基因产物(2)

mRNA Protein Name
NM_001353435.1 NP_001340364.1 DNA polymerase subunit gamma-2, mitochondrial isoform 1b
NM_015810.2 NP_056625.2 DNA polymerase subunit gamma-2, mitochondrial isoform 1a
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-directed DNA polymerase activity IDA
IDA: 通过直接分析推断
10666468 MGI
enables identical protein binding IPI
IPI: 通过物理相互作用推断
11172710 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
23197651 MGI
acts upstream of or within mitochondrial DNA metabolic process IMP
IMP: 通过突变表型推断
23197651 MGI
acts upstream of or within mitochondrial DNA replication IMP
IMP: 通过突变表型推断
23197651 MGI
acts upstream of or within mitochondrion organization IMP
IMP: 通过突变表型推断
23197651 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

DNA polymerase subunit gamma-2, mitochondrial

DNA polymerase gamma accessory 55 kDa subunit

mitochondrial DNA polymerase accessory subunit

mitochondrial polymerase gamma 2

Polg2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Polg2 Q9QZM2 Polg2 Mus musculus Q9QZM2 11172710
种属内
Polg2 Q9QZM2 Polg2 Mus musculus Q9QZM2 11172710
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Polg2 NCBI NCBI:11232