PHF7 - PHD finger protein 7 Gene

中文名称：PHD 指蛋白 7

种属: Homo sapiens

同用名: HSPC045; HSPC226; NYD-SP6

关于 PHF7

功能概要

精子发生是一个复杂的过程，受细胞外和细胞内因素以及睾丸间质细胞、支持细胞和生殖细胞之间的细胞相互作用调节。该基因在支持细胞的睾丸中表达，但在生殖细胞中不表达。该基因编码的蛋白质包含植物同源结构域 (PHD) 指结构域，也称为白血病相关蛋白 (LAP) 结构域，据信参与转录调控。这种定位于转染细胞核的蛋白质与精子发生的转录调节有关。交替剪接导致该基因的多个转录变体。[RefSeq 提供，2013 年 5 月]

Spermatogenesis is a complex process regulated by extracellular and intracellular factors as well as cellular interactions among interstitial cells of the testis, Sertoli cells, and germ cells. This gene is expressed in the testis in Sertoli cells but not germ cells. The protein encoded by this gene contains plant homeodomain (PHD) finger domains, also known as leukemia associated protein (LAP) domains, believed to be involved in transcriptional regulation. The protein, which localizes to the nucleus of transfected cells, has been implicated in the transcriptional regulation of spermatogenesis. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]