2. Gene
  3. Cnr2 - cannabinoid receptor 2 Gene

Cnr2 - cannabinoid receptor 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：大麻素受体 2

种属: Rattus norvegicus

同用名: CB2; CB-2; CB2C; CNR2C

基因 ID: 57302 | 基因类型: protein coding

关于 Cnr2

Primary_assembly 5: 148,125,604-148,151,548 forward strand.mRatBN7.2:CM026978.1

This gene has 4 transcripts (splice variants), 196 orthologues, 18 paralogues and is associated with 28 phenotypes. Biased expression in Spleen (RPKM 23.), Lung (RPKM 25.2) and 5 other tissues.

功能概要

该基因编码的蛋白可启动大麻素受体活性。涉及多个过程，包括 GABA 能突触传递的负调节；肥大细胞活化的负调节；和一氧化氮合酶活性的负调节。位于树突和神经细胞体中。是质膜细胞质侧的外在成分。用于研究亨廷顿病；关节炎;和坐骨神经病。胰腺炎的生物标志物。与人类 CNR2（大麻素受体 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables Cannabinoid Receptor activity. Involved in several processes, including negative regulation of GABAergic synaptic transmission; negative regulation of mast cell activation; and negative regulation of nitric-oxide synthase activity. Located in dendrite and neuronal cell body. Is extrinsic component of cytoplasmic side of plasma membrane. Used to study Huntington's disease; arthritis; and sciatic neuropathy. Biomarker of pancreatitis. Orthologous to human CNR2 (Cannabinoid Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Cnr2 基因产物(3)

mRNA Protein Name
NM_001164143.3 NP_001157615.1 cannabinoid receptor 2 isoform 1
NM_001164142.3 NP_001157614.1 cannabinoid receptor 2 isoform 1
NM_020543.4 NP_065418.3 cannabinoid receptor 2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled receptor activity IDA
IDA: 通过直接分析推断
10688601 RGD
enables cannabinoid receptor activity IDA
IDA: 通过直接分析推断
10688601 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
12084572 RGD
involved in negative regulation of action potential IMP
IMP: 通过突变表型推断
19616018 RGD
involved in negative regulation of mast cell activation IDA
IDA: 通过直接分析推断
18552882 RGD
involved in negative regulation of nitric-oxide synthase activity IMP
IMP: 通过突变表型推断
18561998 RGD
involved in negative regulation of synaptic transmission, GABAergic IMP
IMP: 通过突变表型推断
19616018 RGD
involved in response to amphetamine IEP
IEP: 通过表达模式推断
20067581 RGD
involved in response to lipopolysaccharide IMP
IMP: 通过突变表型推断
18483180 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in dendrite IDA
IDA: 通过直接分析推断
18991891 RGD
located in extrinsic component of cytoplasmic side of plasma membrane IDA
IDA: 通过直接分析推断
18798269 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
18991891 RGD
is active in postsynaptic membrane IDA
IDA: 通过直接分析推断
18991892 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Cnr2 蛋白结构

7tmA_CB2

7tmA_CB2: cd15341 (33 - 309)

7tmA_CB2

7tmA_CB2: cd15341 (34 - 60)

7tmA_CB2

7tmA_CB2: cd15341 (68 - 93)

7tmA_CB2

7tmA_CB2: cd15341 (105 - 135)

7tmA_CB2

7tmA_CB2: cd15341 (147 - 167)

7tmA_CB2

7tmA_CB2: cd15341 (185 - 214)

7tmA_CB2

7tmA_CB2: cd15341 (237 - 267)

7tmA_CB2

7tmA_CB2: cd15341 (277 - 302)

  • 0
  • 100
  • 200
  • 300
  • 410 a.a.
蛋白主名 其他名称

cannabinoid receptor 2

CB2 receptor

cannabinoid receptor 2 (macrophage)

peripheral cannabinoid receptor

rCB2

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-153169 6PPD-Q Inhibitor 99.77% 否
HY-107713 PPDA Antagonist 98.0% 否
HY-12962A NMDA-IN-1 dihydrochloride Antagonist / 否
HY-RS02917 CNR2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS02918 Cnr2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS02919 Cnr2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cnr2 NCBI NCBI:1269
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