1. Gene
  2. NMRAL1 - NmrA like redox sensor 1 Gene

NMRAL1 - NmrA like redox sensor 1 Gene

中文名称:NMRA 类氧化还原传感器 1

种属: Homo sapiens

同用名: HSCARG; SDR48A1

基因 ID: 57407 | 基因类型: protein coding

关于 NMRAL1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:4,461,694-4,476,337 (from NCBI)

This gene has 18 transcripts (splice variants), 1 gene allele and 113 orthologues. Ubiquitous expression in prostate (RPKM 6.2), ovary (RPKM 6.2) and 25 other tissues.

功能概要

该基因编码优先与 NADPH 结合的 NADPH 传感器蛋白。编码的蛋白质还以泛素化依赖的方式负向调节 NF-kappaB 的活性。它通过负向调节干扰素反应因子 3 介导的干扰素 β 表达,在细胞抗病毒反应中发挥关键作用。该基因的可变剪接导致多个转录变体。[RefSeq 提供,2015 年 2 月]

This gene encodes an NADPH sensor protein that preferentially binds to NADPH. The encoded protein also negatively regulates the activity of NF-kappaB in a ubiquitylation-dependent manner. It plays a key role in cellular Antiviral response by negatively regulating the interferon response factor 3-mediated expression of interferon beta. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]

NMRAL1 基因产物(6)

mRNA Protein Name
NM_001305141.3 NP_001292070.1 nmrA-like family domain-containing protein 1 isoform 1
NM_001305142.3 NP_001292071.1 nmrA-like family domain-containing protein 1 isoform 1
NM_001351994.2 NP_001338923.1 nmrA-like family domain-containing protein 1 isoform 1
NM_001351995.2 NP_001338924.1 nmrA-like family domain-containing protein 1 isoform 2
NM_001351996.2 NP_001338925.1 nmrA-like family domain-containing protein 1 isoform 3
NM_020677.6 NP_065728.1 nmrA-like family domain-containing protein 1 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
17496144 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17496144 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

NMRAL1 蛋白结构

NmrA

NmrA: NmrA-like family (7 - 237)

  • 0
  • 100
  • 200
  • 299 a.a.
蛋白主名 其他名称

nmrA-like family domain-containing protein 1

NmrA-like family domain containing 1

NMRAL1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NMRAL1 Q9HBL8 NMRAL1 Homo sapiens Q9HBL8
DLS
17496144
种属内
NMRAL1 Q9HBL8 NMRAL1 Homo sapiens Q9HBL8 17496144
种属内
NMRAL1 Q9HBL8 OPTN Homo sapiens Q96CV9 32814053
种属内
NMRAL1 Q9HBL8 ACTA1 Homo sapiens P68133 33961781
种属内
NMRAL1 Q9HBL8 ASS1 Homo sapiens P00966 17496144
种属内
NMRAL1 Q9HBL8 GALNT1 Homo sapiens Q10472 33961781
种属内
NMRAL1 Q9HBL8 OPTN Homo sapiens Q96CV9 32814053
种属内
NMRAL1 Q9HBL8 ASS1 Homo sapiens P00966 17496144
种属内
NMRAL1 Q9HBL8 TUBA1A Homo sapiens Q71U36 33961781
种属内
NMRAL1 Q9HBL8 HSPA8 Homo sapiens P11142 33961781
种属内
NMRAL1 Q9HBL8 OPTN Homo sapiens Q96CV9 32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Bos taurus NMRAL1 VGNC VGNC:32134
Macaca mulatta NMRAL1 VGNC VGNC:75252
Rattus norvegicus NMRAL1 RGD RGD:1311451
Mus musculus NMRAL1 MGD MGI:1915074
Canis familiaris NMRAL1 VGNC VGNC:103694
Felis catus NMRAL1 VGNC VGNC:63841