2. Gene
  3. MFN2 - Mfn2 mitofusin 2 Gene

MFN2 - Mfn2 mitofusin 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: HSG

基因 ID: 64476 | 基因类型: protein coding

关于 MFN2

功能概要

Enables several functions, including GTP binding activity; identical protein binding activity; and small GTPase binding activity. Involved in several processes, including mitochondrion organization; negative regulation of organelle organization; and regulation of Reactive Oxygen Species biosynthetic process. Located in cytosol and mitochondrial outer membrane. Is intrinsic component of mitochondrial outer membrane. Used to study carotid stenosis. Biomarker of several diseases, including artery disease (multiple); fatty liver disease (multiple); obesity; prediabetes syndrome; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease type 2A2A; Charcot-Marie-Tooth disease type 2A2B; and Charcot-Marie-Tooth disease type 6. Orthologous to human MFN2 (mitofusin 2). [provided by Alliance of Genome Resources, Apr 2022]

MFN2 基因产物(1)

mRNA Protein Name
NM_130894.4 NP_570964.4 mitofusin-2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTP binding IMP
IMP: 通过突变表型推断
15322553 RGD
enables GTPase binding IDA
IDA: 通过直接分析推断
14561718 RGD
enables GTPase binding IPI
IPI: 通过物理相互作用推断
15322553 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
14561718 RGD
enables proteoglycan binding IPI
IPI: 通过物理相互作用推断
25151458 RGD
enables small GTPase binding IDA
IDA: 通过直接分析推断
27997345 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to L-glutamate IEP
IEP: 通过表达模式推断
25416777 RGD
involved in cellular response to dexamethasone stimulus IEP
IEP: 通过表达模式推断
22703557 RGD
involved in cellular response to glucose stimulus IEP
IEP: 通过表达模式推断
28518143 RGD
involved in cellular response to hypoxia IEP
IEP: 通过表达模式推断
23658809 RGD
involved in cellular response to ionizing radiation IEP
IEP: 通过表达模式推断
26415228 RGD
involved in cellular response to low-density lipoprotein particle stimulus IEP
IEP: 通过表达模式推断
26062420 RGD
involved in cellular response to manganese ion IEP
IEP: 通过表达模式推断
28232070 RGD
involved in cellular response to mercaptoethanol IEP
IEP: 通过表达模式推断
26903301 RGD
involved in cellular response to testosterone stimulus IEP
IEP: 通过表达模式推断
26062420 RGD
involved in intracellular distribution of mitochondria IMP
IMP: 通过突变表型推断
19605646 RGD
involved in male gonad development IEP
IEP: 通过表达模式推断
14592431 RGD
involved in mitochondrial calcium ion homeostasis IMP
IMP: 通过突变表型推断
25147362 RGD
involved in mitochondrial fusion IMP
IMP: 通过突变表型推断
14561718 RGD
involved in mitochondrion organization IMP
IMP: 通过突变表型推断
18006463 RGD
involved in negative regulation of cardiac muscle cell apoptotic process IMP
IMP: 通过突变表型推断
28483668 RGD
involved in negative regulation of cell cycle IMP
IMP: 通过突变表型推断
25017825 RGD
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
15322553 RGD
involved in negative regulation of cell size IMP
IMP: 通过突变表型推断
27565029 RGD
involved in negative regulation of glial cell proliferation IMP
IMP: 通过突变表型推断
25017825 RGD
involved in negative regulation of mitochondrial fission IMP
IMP: 通过突变表型推断
28478070 RGD
involved in negative regulation of reactive oxygen species biosynthetic process IMP
IMP: 通过突变表型推断
28483668 RGD
involved in negative regulation of release of cytochrome c from mitochondria IMP
IMP: 通过突变表型推断
18006463 RGD
involved in negative regulation of sarcomere organization IMP
IMP: 通过突变表型推断
24777478 RGD
involved in negative regulation of smooth muscle cell proliferation IDA
IDA: 通过直接分析推断
15322553 RGD
involved in negative regulation of vascular associated smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
28478070 RGD
involved in positive regulation of D-glucose import IMP
IMP: 通过突变表型推断
25034891 RGD
involved in positive regulation of cellular respiration IMP
IMP: 通过突变表型推断
25147362 RGD
involved in positive regulation of dendritic spine morphogenesis IMP
IMP: 通过突变表型推断
19605646 RGD
involved in positive regulation of estradiol secretion IMP
IMP: 通过突变表型推断
25120590 RGD
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
27997345 RGD
involved in positive regulation of hydrogen peroxide biosynthetic process IMP
IMP: 通过突变表型推断
27997345 RGD
involved in positive regulation of insulin receptor signaling pathway IMP
IMP: 通过突变表型推断
25034891 RGD
involved in positive regulation of mitochondrial membrane potential IMP
IMP: 通过突变表型推断
18006463 RGD
involved in positive regulation of ovarian follicle development IMP
IMP: 通过突变表型推断
25120590 RGD
involved in positive regulation of progesterone secretion IMP
IMP: 通过突变表型推断
25120590 RGD
involved in positive regulation of reactive oxygen species biosynthetic process IMP
IMP: 通过突变表型推断
27997345 RGD
involved in response to D-galactose IEP
IEP: 通过表达模式推断
28302704 RGD
involved in response to L-arginine IEP
IEP: 通过表达模式推断
28483572 RGD
involved in response to axon injury IEP
IEP: 通过表达模式推断
23220115 RGD
involved in response to cadmium ion IEP
IEP: 通过表达模式推断
25388156 RGD
involved in response to calcium ion IEP
IEP: 通过表达模式推断
25308841 RGD
involved in response to electrical stimulus IEP
IEP: 通过表达模式推断
26513006 RGD
involved in response to fatty acid IEP
IEP: 通过表达模式推断
25034891 RGD
involved in response to flavonoid IEP
IEP: 通过表达模式推断
24637344 RGD
involved in response to hypobaric hypoxia IEP
IEP: 通过表达模式推断
24637344 RGD
involved in response to muscle activity IEP
IEP: 通过表达模式推断
19716857 RGD
involved in response to nutrient levels IEP
IEP: 通过表达模式推断
25336449 RGD
involved in response to testosterone IEP
IEP: 通过表达模式推断
25770118 RGD
involved in spermatogenesis IEP
IEP: 通过表达模式推断
14592431 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
11950885 RGD
located in mitochondrial outer membrane IDA
IDA: 通过直接分析推断
11950885 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

mitofusin-2

hypertension-related protein

mitochondrial transmembrane GTPase FZO1A

mitofusin-2-like

transmembrane GTPase MFN2

相关产品

Pre-clinical Phase
生物活性分子 (11)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-150031 MFI8 Inhibitor 99.67% 否
HY-W187305 MASM7 99.85% 否
HY-126124 AP39 96.35% 否
HY-123985 MFN2 agonist-1 Activator 98.84% 否
HY-W018587 TBPH 95.0% 否
HY-13338 Mabuterol Agonist 99.96% 否
HY-RS08384 MFN2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-152051S Mabuterol-d9 hydrochloride Agonist / 否
HY-RS17108 Mfn2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23553 Mfn2 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-W755295 Mabuterol hydrochloride Agonist / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens MFN2 NCBI NCBI:9927
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