2. Gene
  3. PDIA2 - protein disulfide isomerase family A member 2 Gene

PDIA2 - protein disulfide isomerase family A member 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白质二硫键异构酶家族 A 成员 2

种属: Homo sapiens

同用名: PDI; PDA2; PDIP; PDIR

基因 ID: 64714 | 基因类型: protein coding

关于 PDIA2

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:283,164-287,215 (from NCBI)

This gene has 7 transcripts (splice variants), 335 orthologues and 13 paralogues. Biased expression in pancreas (RPKM 284.3) and stomach (RPKM 33.5).

功能概要

该基因编码内质网 (ER) 蛋白二硫化物异构酶 (PDI) 家族的成员，该蛋白催化蛋白质折叠和硫醇-二硫化物交换反应。编码的蛋白质具有一个 N 端 ER 信号序列、两个催化活性硫氧还蛋白 (TRX) 结构域、两个 TRX 样结构域和一个 C 端 ER 保留序列。该蛋白质通过其硫醇异构酶、氧化酶和还原酶活性形成二硫键，从而在内质网中的新生蛋白质的折叠中发挥作用。编码的蛋白质还具有雌二醇结合活性，可以调节细胞内雌二醇水平。[RefSeq 提供，2017 年 9 月]

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. The protein plays a role in the folding of nascent proteins in the endoplasmic reticulum by forming disulfide bonds through its thiol isomerase, oxidase, and reductase activity. The encoded protein also possesses estradiol-binding activity and can modulate intracellular estradiol levels. [provided by RefSeq, Sep 2017]

PDIA2 基因产物(1)

mRNA Protein Name
NM_006849.4 NP_006840.2 protein disulfide-isomerase A2 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17474147 GOA
enables protein-disulfide reductase activity IDA
IDA: 通过直接分析推断
16677074 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PDIA2 蛋白结构

Thioredoxin

Thioredoxin: Thioredoxin (58 - 149)

Thioredoxin_6

Thioredoxin_6: Thioredoxin-like domain (179 - 365)

Thioredoxin

Thioredoxin: Thioredoxin (390 - 492)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 525 a.a.
蛋白主名 其他名称

protein disulfide-isomerase A2

Rho GDP dissociation inhibitor gamma

PDIA2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PDIA2 Q13087 KRTAP6-1 Homo sapiens Q3LI64
Validated Y2H
32296183
种属内
PDIA2 Q13087 NCK1 Homo sapiens P16333
Peptide Array
17474147
种属间: 跨种属相互作用 种属内: 同种属相互作用

PDIA2 抗体

目录号 产品名 应用 反应物种
HY-P80270 PDIA2 Antibody (YA238) WB, FC Human, Mouse, Rat

关联疾病

疾病名称 别名
Abetalipoproteinemia

Acanthocytosis

ABL

Bassen-Kornzweig Syndrome

Mtp Deficiency

Familial Hypobetalipoproteinemia

Abetalipoproteinaemia

Microsomal Triglyceride Transfer Protein Deficiency

Microsomal Triglyceride Transfer Protein Deficiency Disease

Abetalipoproteinemia Neuropathy

Apolipoprotein B Deficiency

Bassen-Kornzweig Disease

Betalipoprotein Deficiency Disease

Congenital Betalipoprotein Deficiency Syndrome

Homozygous Familial Hypobetalipoproteinemia

Fhbl

Bassen Kornzweig Syndrome

Hypobetalipoproteinemia, Familial

Hypobetalipoproteinemia

Hypobetalipoproteinemias

Hypobetalipoproteinemia, Familial, Apolipoprotein B
Alpha Thalassemia-Intellectual Disability Syndrome Type 1

Alpha Thalassemia-Intellectual Disability Syndrome, Deletion Type

Alpha-Thalassemia-Intellectual Disability Syndrome Linked To Chromosome 16

Atr Syndrome Linked To Chromosome 16

Atr Syndrome, Deletion Type

Atr-16 Syndrome

Alpha Thalassemia-Retardation Syndrome

Alpha-Thalassemia/Mental Retardation Syndrome, Deletion-Type

Alpha-Thalassemia/Mental Retardation Syndrome, Type 1

Alpha-Thalassemia Mental Retardation Syndrome, Deletion-Type
Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm

Annuloaortic Ectasia

Familial Thoracic Aortic Aneurysm And Aortic Dissection

Familial Aortic Dissection

Familial Taad

Familial Thoracic Aortic Aneurysm

Congenital Aneurysm Of Ascending Aorta

Familial Aortic Aneurysm

Familial Thoracic Aortic Aneurysm And Dissection

Aortic Aneurysm, Thoracic

AAT1

Faa1

Aortic Dissection, Familial

Aortic Aneurysm, Familial Thoracic

Aneurysm, Thoracic Aortic

Faa

Ftaad

Taa

Taad

Cystic Medial Necrosis Of Aorta

Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection

Aortic Aneurysm Thoracic

Familial Aortic Aneurysms

Aneurysm, Aortic, Thoracic, Familial, Type 1

Aneurysm Of Thoracic Aorta

Intrathoracic Aneurysm

Thoracic Aorta Aneurysm

Thoracic Aortic Aneurysm Without Rupture

Thoracic Aneurysm

Thorax Arterial Aneurysm

Thoracic Artery Aneurysm

Thoracic Arterial Aneurysm

Thorax Aneurysm

Thorax Aortic Aneurysm

Dissection Of Thoracic Aorta
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10265 PDIA2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22713 Pdia2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS29227 Pdia2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PDIA2 VGNC VGNC:32696
Macaca mulatta PDIA2 VGNC VGNC:75799
Felis catus PDIA2 VGNC VGNC:82326
Mus musculus PDIA2 MGD MGI:1916441
Rattus norvegicus PDIA2 RGD RGD:1305164
Canis familiaris PDIA2 VGNC VGNC:44376
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