2. Gene
  3. Tsc1 - TSC complex subunit 1 Gene

Tsc1 - TSC complex subunit 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

基因 ID: 64930 | 基因类型: protein coding

关于 Tsc1

功能概要

Enables ATPase inhibitor activity and protein N-terminus binding activity. Involved in associative learning; negative regulation of ATPase activity; and protein stabilization. Acts upstream of or within several processes, including animal organ development; negative regulation of cell size; and nervous system development. Located in cytoplasm. Is active in postsynaptic density. Is expressed in several structures, including central nervous system; genitourinary system; hepatic primordium; liver; and retina. Used to study anterior segment dysgenesis; autism spectrum disorder; autosomal recessive polycystic kidney disease; and tuberous sclerosis. Human ortholog(s) of this gene implicated in intellectual disability; lymphangioleiomyomatosis; tuberous sclerosis; and tuberous sclerosis 1. Orthologous to human TSC1 (TSC complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Tsc1 基因产物(3)

mRNA Protein Name
NM_001289575.2 NP_001276504.1 hamartin isoform 1
NM_001289576.2 NP_001276505.1 hamartin isoform 3
NM_022887.5 NP_075025.2 hamartin isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATPase inhibitor activity IMP
IMP: 通过突变表型推断
29127155 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
10806479 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within D-glucose import IMP
IMP: 通过突变表型推断
18511518 MGI
acts upstream of or within adaptive immune response IMP
IMP: 通过突变表型推断
25271321 MGI
involved in associative learning IMP
IMP: 通过突变表型推断
26158416 MGI
acts upstream of or within cardiac muscle cell differentiation IMP
IMP: 通过突变表型推断
11438694 MGI
acts upstream of cell population proliferation IMP
IMP: 通过突变表型推断
11438694 MGI
acts upstream of or within cell projection organization IMP
IMP: 通过突变表型推断
16286931 MGI
acts upstream of or within cerebral cortex development IMP
IMP: 通过突变表型推断
17522300 MGI
acts upstream of or within embryo development IMP
IMP: 通过突变表型推断
15888477 MGI
acts upstream of or within hippocampus development IMP
IMP: 通过突变表型推断
17522300 MGI
acts upstream of or within kidney development IMP
IMP: 通过突变表型推断
15888477 MGI
acts upstream of or within memory T cell differentiation IMP
IMP: 通过突变表型推断
25271321 MGI
acts upstream of or within myelination IMP
IMP: 通过突变表型推断
17522300 MGI
involved in negative regulation of ATP-dependent activity IMP
IMP: 通过突变表型推断
29127155 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
11438694 MGI
acts upstream of or within negative regulation of cell size IGI
IGI: 通过遗传相互作用推断
15185396 MGI
acts upstream of or within negative regulation of cell size IMP
IMP: 通过突变表型推断
15664737 MGI
acts upstream of or within nervous system development IMP
IMP: 通过突变表型推断
17522300 MGI
acts upstream of or within neural tube closure IMP
IMP: 通过突变表型推断
11438694 MGI
acts upstream of or within potassium ion transport IGI
IGI: 通过遗传相互作用推断
16393152 MGI
acts upstream of or within potassium ion transport IMP
IMP: 通过突变表型推断
16393152 MGI
involved in protein stabilization IMP
IMP: 通过突变表型推断
29127155 MGI
acts upstream of or within regulation of protein kinase activity IGI
IGI: 通过遗传相互作用推断
15185396 MGI
acts upstream of or within synapse organization IMP
IMP: 通过突变表型推断
16286931 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11741832 MGI
is active in postsynaptic density EXP
EXP: 通过实验结果推断
25211037 MGI
is active in postsynaptic density IDA
IDA: 通过直接分析推断
25211037 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

hamartin

tuberous sclerosis 1 protein homolog

Tsc1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Tsc1 Q9EP53 Tsc2 Mus musculus Q61037
Anti Bait CoIP
28671696
种属内
Tsc1 Q9EP53 Tsc2 Mus musculus Q61037
Anti Bait CoIP
20412061
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-134904 RMC-6272 Inhibitor 97.42% 否
HY-131976 BVDV-IN-1 Inhibitor 98.51% 否
HY-RS15131 TSC1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17222 Tsc1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-134922 NS1-IN-1 Inhibitor / 否
HY-RS02096 CCL26 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-174756 Human CCL26 mRNA / 否
HY-RS23675 Tsc1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tsc1 NCBI NCBI:7248
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