2. Gene
  3. Ryr2 - ryanodine receptor 2 Gene

Ryr2 - ryanodine receptor 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: RyR; RYR-2

基因 ID: 689560 | 基因类型: protein coding

关于 Ryr2

功能概要

Enables calcium-induced calcium release activity; ryanodine-sensitive calcium-release channel activity; and scaffold protein binding activity. Involved in several processes, including metal ion transport; negative regulation of cytosolic calcium ion concentration; and response to magnesium ion. Located in several cellular components, including A band; sarcolemma; and sarcoplasmic reticulum membrane. Is extrinsic component of cytoplasmic side of plasma membrane. Part of protein-containing complex. Colocalizes with Z disc. Used to study congestive heart failure. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy; arrhythmogenic right ventricular dysplasia 2; and catecholaminergic polymorphic ventricular tachycardia 1. Orthologous to human RYR2 (ryanodine receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Ryr2 基因产物(2)

mRNA Protein Name
NM_001191043.3 NP_001177972.2 ryanodine receptor 2 isoform 2
NM_032078.3 NP_114467.2 ryanodine receptor 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium-induced calcium release activity IDA
IDA: 通过直接分析推断
18799678 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
15010472 RGD
enables ryanodine-sensitive calcium-release channel activity IDA
IDA: 通过直接分析推断
18799678 RGD
enables ryanodine-sensitive calcium-release channel activity IMP
IMP: 通过突变表型推断
21807619 RGD
enables scaffold protein binding IPI
IPI: 通过物理相互作用推断
11590243 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in calcium ion transmembrane transport IMP
IMP: 通过突变表型推断
19116207 RGD
involved in manganese ion transmembrane transport IMP
IMP: 通过突变表型推断
19116207 RGD
involved in monoatomic ion transmembrane transport IMP
IMP: 通过突变表型推断
19116207 RGD
involved in negative regulation of cytosolic calcium ion concentration IDA
IDA: 通过直接分析推断
18799678 RGD
involved in regulation of cytosolic calcium ion concentration IMP
IMP: 通过突变表型推断
15870112 RGD
involved in response to calcium ion IDA
IDA: 通过直接分析推断
17027851 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
22962011 RGD
involved in response to magnesium ion IDA
IDA: 通过直接分析推断
16971497 RGD
involved in response to nutrient IEP
IEP: 通过表达模式推断
17224993 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
15916736 RGD
involved in sarcoplasmic reticulum calcium ion transport IMP
IMP: 通过突变表型推断
21807619 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in A band IDA
IDA: 通过直接分析推断
17627991 RGD
located in Z disc IDA
IDA: 通过直接分析推断
11053140 RGD
located in extrinsic component of cytoplasmic side of plasma membrane IDA
IDA: 通过直接分析推断
20177054 RGD
located in nuclear envelope IDA
IDA: 通过直接分析推断
11590243 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
16306226 RGD
located in sarcolemma IDA
IDA: 通过直接分析推断
21474431 RGD
located in sarcoplasmic reticulum IDA
IDA: 通过直接分析推断
11590243 RGD
located in sarcoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
11053140 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

ryanodine receptor 2

cardiac muscle ryanodine receptor

cardiac muscle ryanodine receptor-calcium release channel

cardiac-type ryaodine receptor

ryanodine receptor 2, cardiac

ryanodine receptor type II

type 2 ryanodine receptor

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-W010950 Flecainide Inhibitor 99.98% 否
HY-W010950A Flecainide hydrochloride Inhibitor 99.93% 否
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-119850 Aladorian Inhibitor 99.55% Phase 2
Pre-clinical Phase
生物活性分子 (17)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-149662 TMDJ-035 Inhibitor 99.92% 否
HY-15292 S107 Ligand 99.77% 否
HY-N7491A Ent-(+)-Verticilide Inhibitor 99.91% 否
HY-P5114A Maurocalcine TFA Agonist 95.09% 否
HY-RS12369 RYR2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-103059 SOICR-IN-1 99.62% 否
HY-P5114 Maurocalcine Agonist / 否
HY-Z7733 O-Desmethylcarvedilol Inhibitor 97.4% 否
HY-119850A Aladorian sodium Inhibitor / 否
HY-178344 Multi-target kinase-IN-6 / 否
HY-P5319 MCaE12A / 否
HY-149779 RyR2 stabilizer-1 Modulator / 否
HY-164631 EL20 Inhibitor / 否
HY-166478S O-Desmethyl carvedilol-d5 Inhibitor / 否
HY-RS19951 Ryr2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26453 Ryr2 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-W010950S Flecainide-d3 / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ryr2 NCBI NCBI:6262
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