2. Gene
  3. KNDC1 - kinase non-catalytic C-lobe domain containing 1 Gene

KNDC1 - kinase non-catalytic C-lobe domain containing 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含激酶非催化 C 叶结构域 1

种属: Homo sapiens

同用名: v-KIND; RASGEF2; C10orf23; Very-KIND; bB439H18.3

基因 ID: 85442 | 基因类型: protein coding

关于 KNDC1

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:133,160,219-133,226,412 (from NCBI)

This gene has 24 transcripts (splice variants) and 221 orthologues. Biased expression in brain (RPKM 6.5), ovary (RPKM 2.2) and 6 other tissues.

功能概要

由该基因编码的蛋白质是一种 Ras 鸟嘌呤核苷酸交换因子，它似乎可以负向调节大脑中的树突生长。在衰老的脐静脉内皮细胞中敲除该基因可部分逆转衰老，表明该基因可能成为抗衰老疗法的目标。[RefSeq 提供，2016 年 12 月]

The protein encoded by this gene is a Ras guanine nucleotide exchange factor that appears to negatively regulate dendritic growth in the brain. Knockdown of this gene in senescent umbilical vein endothelial cells partially reversed the senescence, showing that this gene could potentially be targeted by Anti-aging therapies. [provided by RefSeq, Dec 2016]

KNDC1 基因产物(4)

mRNA Protein Name
NM_001347864.2 NP_001334793.1 kinase non-catalytic C-lobe domain-containing protein 1 isoform 2
NM_001347865.2 NP_001334794.1 kinase non-catalytic C-lobe domain-containing protein 1 isoform 3
NM_001347866.2 NP_001334795.1 kinase non-catalytic C-lobe domain-containing protein 1 isoform 4
NM_152643.8 NP_689856.6 kinase non-catalytic C-lobe domain-containing protein 1 isoform 1

KNDC1 蛋白结构

RasGEF_N

RasGEF_N: RasGEF N-terminal motif (1250 - 1348)

RasGEF

RasGEF: RasGEF domain (1466 - 1673)

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  • 1749 a.a.
蛋白主名 其他名称

kinase non-catalytic C-lobe domain-containing protein 1

KIND domain-containing protein 1

关联疾病

疾病名称 别名
Joubert Syndrome 31

JBTS31
Brugada Syndrome 9

BRGDA9

Brugada Syndrome, Type 9
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07410 KNDC1 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus KNDC1 VGNC VGNC:82414
Mus musculus KNDC1 MGD MGI:1923734
Rattus norvegicus KNDC1 RGD RGD:1565261
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