2. Gene
  3. Rpe65 - retinoid isomerohydrolase RPE65 Gene

Rpe65 - retinoid isomerohydrolase RPE65 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 89826 | 基因类型: protein coding

关于 Rpe65

功能概要

Enables all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity. Involved in several processes, including circadian rhythm; neural retina development; and retinoid metabolic process. Located in cell body. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 2; retinitis pigmentosa; retinitis pigmentosa 20; and retinitis pigmentosa 87. Orthologous to human RPE65 (retinoid isomerohydrolase RPE65). [provided by Alliance of Genome Resources, Apr 2022]

Rpe65 基因产物(1)

mRNA Protein Name
NM_053562.3 NP_446014.2 retinoid isomerohydrolase
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity IMP
IMP: 通过突变表型推断
21785167 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in camera-type eye development IEP
IEP: 通过表达模式推断
9512345 RGD
involved in circadian rhythm IEP
IEP: 通过表达模式推断
12742352 RGD
involved in neural retina development IDA
IDA: 通过直接分析推断
2631392 RGD
involved in response to light stimulus IEP
IEP: 通过表达模式推断
17389522 RGD
involved in retinal metabolic process IMP
IMP: 通过突变表型推断
21785167 RGD
involved in retinol metabolic process IDA
IDA: 通过直接分析推断
3603006 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell body IDA
IDA: 通过直接分析推断
19180257 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

retinoid isomerohydrolase

RPE65, retinoid isomerohydrolase

all-trans-retinyl-palmitate hydrolase

lutein isomerase

meso-zeaxanthin isomerase

retinal pigment epithelium 65

retinal pigment epithelium 65-like

retinal pigment epithelium-specific 65 kDa protein

retinal pigment ep

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-19720A Emixustat hydrochloride 99.29% Phase 3
HY-19720 Emixustat 98.00% Phase 3
Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-149325 RPE65-IN-1 ≥98.0% 否
HY-119059 CU239 Inhibitor / 否
HY-175663 EYE-002 Inhibitor / 否
HY-175664 EYE-003 Inhibitor / 否
HY-RS12151 RPE65 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22780 Rpe65 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS29294 Rpe65 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Rpe65 NCBI NCBI:6121
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