2. Gene
  3. PAGE4 - PAGE family member 4 Gene

PAGE4 - PAGE family member 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品

中文名称：PAGE 家族成员 4

种属: Homo sapiens

同用名: JM27; JM-27; CT16.7; GAGE-9; GAGEC1; PAGE-1; PAGE-4

基因 ID: 9506 | 基因类型: protein coding

关于 PAGE4

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:49,829,260-49,834,264 (from NCBI)

This gene has 4 transcripts (splice variants), 47 orthologues and 22 paralogues. Restricted expression toward placenta (RPKM 272.2).

功能概要

该基因是 GAGE 家族的成员。 GAGE 基因在多种肿瘤和一些胎儿和生殖组织中表达。该基因在前列腺和前列腺癌中强烈表达。它还在其他男性和女性生殖组织中表达，包括睾丸、输卵管、子宫和胎盘，以及睾丸癌和子宫癌。由该基因编码的蛋白质与其他 GAGE/PAGE 蛋白质具有序列相似性，也属于 CT (癌症-睾丸) 抗原家族。该蛋白质可能在良性和恶性前列腺疾病中发挥作用。一个相关的假基因位于 7 号染色体上。交替剪接导致多个转录本变体。[RefSeq 提供，2016 年 1 月]

This gene is a member of the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in prostate and prostate Cancer. It is also expressed in Other male and female reproductive tissues including testis, fallopian tube, uterus, and placenta, as well as in testicular Cancer and uterine Cancer. The protein encoded by this gene shares sequence similarity with Other GAGE/PAGE proteins, and also belongs to a family of CT (cancer-testis) antigens. The protein may play a role in benign and malignant prostate diseases. A related pseudogene is located on chromosome 7. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

PAGE4 基因产物(2)

mRNA Protein Name
NM_001318877.1 NP_001305806.1 P antigen family member 4
NM_007003.4 NP_008934.1 P antigen family member 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
21357425 GOA
enables nucleic acid binding EXP
EXP: 通过实验结果推断
21357425 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
24263171 GOA
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
24263171 GOA
enables transcription coactivator activity IMP
IMP: 通过突变表型推断
24559171 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
30658679 GOA
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
25374899 GOA
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
21357425 GOA
involved in negative regulation of reactive oxygen species biosynthetic process IDA
IDA: 通过直接分析推断
25374899 GOA
involved in response to starvation IDA
IDA: 通过直接分析推断
25374899 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12489849 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
25374899 GOA
located in nucleus IDA
IDA: 通过直接分析推断
24559171 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PAGE4 蛋白结构

GAGE

GAGE: GAGE protein (1 - 102)

  • 0
  • 102 a.a.
蛋白主名 其他名称

P antigen family member 4

P antigen family, member 4 (prostate associated)

PAGE4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PAGE4 O60829 JUN Homo sapiens P05412
NMR
26242913
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Testicular Cancer

Testis Cancer

Testicular Carcinoma

Testicular Neoplasms

Malignant Neoplasm Of Testis

Childhood Neoplasm Of The Testis

Neoplasm Of Testis

Pediatric Testicular Neoplasm

Testicular Tumor

Testis Neoplasm

Testicular Tumors

Testicular Neoplasm

Testicular Malignant Germ Cell Tumor

Childhood Testicular Neoplasm

Carcinoma Of The Testis

Cancer Of Testis

Malignant Neoplasm Of Testis, Nos

Malignant Neoplasm Of Testis, Unspecified

Malignant Tumour Of Testis

Testicle Cancer

Primary Malignant Neoplasm Of Testis
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Progesterone-Receptor Negative Breast Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09976 PAGE4 Human Pre-designed siRNA Set A Pre-designed Set / 否
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