2. Gene
  3. Cul4a - cullin 4A Gene

Cul4a - cullin 4A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: 2810470J21Rik

基因 ID: 99375 | 基因类型: protein coding

关于 Cul4a

功能概要

Predicted to enable ubiquitin protein Ligase binding activity and ubiquitin-protein transferase activity. Involved in in utero embryonic development and ribosome biogenesis. Acts upstream of or within several processes, including negative regulation of granulocyte differentiation; positive regulation of G1/S transition of mitotic cell cycle; and regulation of response to DNA damage stimulus. Predicted to be part of Cul4A-RING E3 ubiquitin Ligase complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and musculoskeletal system. Orthologous to human CUL4A (cullin 4A). [provided by Alliance of Genome Resources, Apr 2022]

Cul4a 基因产物(3)

mRNA Protein Name
NM_001363448.1 NP_001350377.1 cullin-4A isoform 2
NM_001363450.1 NP_001350379.1 cullin-4A isoform 3
NM_146207.3 NP_666319.2 cullin-4A isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16467204 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response EXP
EXP: 通过实验结果推断
22118460 MGI
acts upstream of cell population proliferation IDA
IDA: 通过直接分析推断
16467204 MGI
involved in cellular response to UV EXP
EXP: 通过实验结果推断
22118460 MGI
acts upstream of or within hemopoiesis IMP
IMP: 通过突变表型推断
18339895 MGI
involved in in utero embryonic development IMP
IMP: 通过突变表型推断
12077329 MGI
acts upstream of or within negative regulation of granulocyte differentiation IDA
IDA: 通过直接分析推断
12393421 MGI
acts upstream of or within positive regulation of G1/S transition of mitotic cell cycle IMP
IMP: 通过突变表型推断
19056892 MGI
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
16467204 MGI
acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
16467204 MGI
acts upstream of or within regulation of DNA damage checkpoint IMP
IMP: 通过突变表型推断
19481525 MGI
acts upstream of or within regulation of nucleotide-excision repair IMP
IMP: 通过突变表型推断
19481525 MGI
acts upstream of or within regulation of protein metabolic process IMP
IMP: 通过突变表型推断
19056892 MGI
involved in ribosome biogenesis IMP
IMP: 通过突变表型推断
26711351 MGI
acts upstream of or within somatic stem cell population maintenance IMP
IMP: 通过突变表型推断
17616641 MGI
acts upstream of or within ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
19481525 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Cul4A-RING E3 ubiquitin ligase complex EXP
EXP: 通过实验结果推断
22118460 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

cullin-4A

CUL-4A

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-148602 KH-4-43 Inhibitor 99.72% 否
HY-161166 MM-02-57 / 否
HY-181164 PROTAC BRD4 Degrader-43 / 否
HY-P11640 Vpr (1-14) Inhibitor / 否
HY-RS03362 CUL4A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22460 Cul4a Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28983 Cul4a Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cul4a NCBI NCBI:8451
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