2. Gene
  3. GOLGA5 - golgin A5 Gene

GOLGA5 - golgin A5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：高金 A5

种属: Homo sapiens

同用名: RFG5; GOLIM5; ret-II

基因 ID: 9950 | 基因类型: protein coding

关于 GOLGA5

Cytogenetic location: 14q32.12 Genomic coordinates (GRCh38): 14:92,794,305-92,839,947 (from NCBI)

This gene has 3 transcripts (splice variants), 200 orthologues and is associated with 69 phenotypes. Ubiquitous expression in testis (RPKM 23.6), thyroid (RPKM 21.8) and 25 other tissues.

功能概要

参与分泌途径中蛋白质和脂质的糖基化和转运的高尔基体由一系列堆叠的池 (扁平膜囊) 组成。高尔基体和微管之间的相互作用被认为对于高尔基体在有丝分裂过程中断裂后的重组很重要。该基因编码一种 golgins，这是一个定位于高尔基体的蛋白质家族。这种蛋白质是一种卷曲螺旋膜蛋白，已被假定在囊泡束缚和对接中发挥作用。已在肿瘤组织中发现涉及该基因和 RET 原癌基因的易位；嵌合序列已命名为 RET-II 和 PTC5。该基因的假基因位于 5 号染色体的短臂上。[RefSeq 提供，2013 年 7 月]

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during Mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein is a coiled-coil membrane protein that has been postulated to play a role in vesicle tethering and docking. Translocations involving this gene and the RET proto-oncogene have been found in tumor tissues; the chimeric sequences have been designated RET-II and PTC5. A pseudogene of this gene is located on the short arm of chromosome 5. [provided by RefSeq, Jul 2013]

GOLGA5 基因产物(1)

mRNA Protein Name
NM_005113.4 NP_005104.4 golgin subfamily A member 5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
9915833 GOA
enables small GTPase binding IDA
IDA: 通过直接分析推断
12538640 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Golgi organization IMP
IMP: 通过突变表型推断
12538640 GOA
involved in Golgi vesicle transport IMP
IMP: 通过突变表型推断
12538640 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
9915833 GOA
located in Golgi cisterna IDA
IDA: 通过直接分析推断
12538640 GOA
located in cis-Golgi network IDA
IDA: 通过直接分析推断
12538640 GOA
located in membrane IDA
IDA: 通过直接分析推断
9915833 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GOLGA5 蛋白结构

Golgin_A5

Golgin_A5: Golgin subfamily A member 5 (235 - 711)

  • 0
  • 200
  • 400
  • 600
  • 731 a.a.
蛋白主名 其他名称

golgin subfamily A member 5

RET-fused gene 5 protein

关联疾病

疾病名称 别名
Differentiated Thyroid Carcinoma

Papillary Or Follicular Thyroid Carcinoma

Well-Differentiated Thyroid Carcinoma

Differentiated Thyroid Gland Carcinoma
Congenital Disorder Of Glycosylation, Type Iig

CDG2G

Congenital Disorder Of Glycosylation Type Iig

Cdg Iig

Cdgiig

Cdgii/Cog1 Cerebrocostomandibular-Like Syndrome

Carbohydrate Deficient Glycoprotein Syndrome Type Iig

Cdg-Iig

Congenital Disorder Of Glycosylation, Type 2g

Cog1-Cdg

Cdg Syndrome Type Iig

Congenital Disorder Of Glycosylation Type 2g

Congenital Disorder Of Glycosylation 2g

Cdg-Ii Caused By Cog1 Deficiency

Glycosylation, Congenital Disorder Of, Type Iig
Chlamydia

Chlamydial Infection

Chlamydia Trachomatis Infectious Disease

Chlamydial Disease

Chlamydia Infections
Congenital Disorder Of Glycosylation, Type In

Congenital Disorder Of Glycosylation

CDG1N

Congenital Disorders Of Glycosylation

Cdg In

Cdgin

Congenital Disorder Of Glycosylation 1n

Carbohydrate-Deficient Glycoprotein Syndrome

Cdg

Rft1-Cdg

Cdg-In

Congenital Disorder Of Glycosylation Type In

Carbohydrate Deficient Glycoprotein Syndrome

Cdg Syndrome

Congenital Disorder Of Glycosylation In

Carbohydrate-Deficient Glycoprotein Syndromes

Cdg Syndrome Type In

Carbohydrate Deficient Glycoprotein Syndrome Type In

Congenital Disorder Of Glycosylation Type 1n

Man5glcnac2-Pp-Dol Flippase Deficiency

Glycosylation, Congenital Disorder Of

Glycosylation, Congenital Disorder Of, Type In
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05586 GOLGA5 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris GOLGA5 VGNC VGNC:41341
Macaca mulatta GOLGA5 VGNC VGNC:73108
Rattus norvegicus GOLGA5 RGD RGD:1308163
Felis catus GOLGA5 VGNC VGNC:62640
Bos taurus GOLGA5 VGNC VGNC:29486
Mus musculus GOLGA5 MGD MGI:1351475
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