2. Anti-infection Cell Cycle/DNA Damage
  3. Bacterial DNA/RNA Synthesis
  4. GyrB-IN-1

GyrB-IN-1 是一种 DNA 促旋酶 (GyrB) 抑制剂。GyrB-IN-1 对耻垢分枝杆菌 GyrB ATP 酶活性的 IC50 为 19.1 μM，对结核分枝杆菌 GyrB DNA 超螺旋活性的 IC50 为 21.9 μM。GyrB-IN-1 具有抗分枝杆菌活性和细胞毒性。GyrB-IN-1 可用于结核病的研究。

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GyrB-IN-1

GyrB-IN-1 Chemical Structure

CAS No. : 1870007-38-7

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GyrB-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GyrB-IN-1 is a DNA gyrase (GyrB) inhibitor. GyrB-IN-1 shows an IC50 of 19.1 μM against Mycobacterium smegmatis GyrB ATPase activity and 21.9 μM against Mycobacterium tuberculosis GyrB DNA supercoiling activity. GyrB-IN-1 exerts antimycobacterial activity and has cytotoxicity. GyrB-IN-1 can be used for the research of tuberculosis[1].

体外研究
(In Vitro)

GyrB-IN-1 (Compound 13) 可抑制耻垢分枝杆菌 (M. smegmatis) GyrB ATP 酶活性，其 IC50 为 19.1 ± 1.8 μM[1]。
GyrB-IN-1 可抑制结核分枝杆菌 (M. tuberculosis) GyrB 介导的 DNA 超螺旋活性，其 IC50 为 21.9 ± 4.2 μM[1]。
GyrB-IN-1 可抑制结核分枝杆菌 H37Rv 菌株的生长，其 MIC 为 30.8 μM[1]。
GyrB-IN-1 (100 μM) 可在 RAW 264.7 细胞中诱导 22.35% 的细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GyrB-IN-1 相关抗体:
分子量

405.86

Formula

C21H12ClN3O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GyrB-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GyrB-IN-11870007-38-7BacterialDNA/RNA Synthesismouse macrophage cellsRAW 264.7 cellstuberculosisMycobacterium tuberculosis GyrB ATPase domainMycobacterium gyrase BMycobacterium tuberculosis H37Rv strainGyrB ATPase activityDNA supercoiling activityMycobacterium smegmatis GyrB ATPase domainInhibitorinhibitorinhibit

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