2. Immunology/Inflammation Membrane Transporter/Ion Channel Metabolic Enzyme/Protease
  3. Toll-like Receptor (TLR) Potassium Channel Phosphatase
  4. HCN-IN-1

HCN-IN-1 是一种 TLR4 抑制剂和 HCN2/HCN4 通道调节剂。HCN-IN-1 不仅能抑制 TLR4 介导的 TLR4 碱性磷酸酶 (SEAP) 信号活性，还能通过降低 HCN2 电流、改变其电压依赖性激活及动力学，并阻断 HCN4 电流来发挥药理作用。HCN-IN-1 镇痛、抗炎和抗心绞痛活性，适用于炎性疼痛、神经性疼痛、心力衰竭及炎症的相关研究。

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HCN-IN-1

HCN-IN-1 Chemical Structure

CAS No. : 2234283-04-4

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HCN-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Toll-like Receptor (TLR) 亚型特异性产品:

查看所有亚型
TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HCN-IN-1 is a TLR4 inhibitor and HCN channel modulator with activity against HCN2 and HCN4.HCN-IN-1 inhibits TLR4-mediated alkaline phosphatase (SEAP) signal activity.HCN-IN-1 reduces HCN2 current across tested voltages, shifts voltage-dependent activation to more hyperpolarized potentials, slows activation kinetics, and does not affect deactivation process.HCN-IN-1 blocks HCN4 current.HCN-IN-1 exhibits analgesic, anti-inflammatory, and anti-anginal effects.HCN-IN-1 can be used for the research of inflammatory pain, neuropathic pain, heart failure, inflammation[1].

IC50 & Target

TLR4

 

KCNQ2

 

KCNQ4

 

体外研究
(In Vitro)

HCN-IN-1 (compound 5) (0.39-100 μM; 24 h) 可浓度依赖性地抑制 HEK BLUE TLR4 细胞中 TLR4 碱性磷酸酶 (SEAP) 的信号强度，在 25 μM 及以上浓度时可观察到显著抑制作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HCN-IN-1 相关抗体:
分子量

484.07

Formula

C28H38ClN3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HCN-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HCN-IN-12234283-04-4Toll-like Receptor (TLR)Potassium ChannelPhosphataseKcsAHCN channelheart failureTLR4HCN2SEAPneuropathic painalkaline phosphataseHCN4inflammatory painHEK BLUE TLR4 cellsInhibitorinhibitorinhibit

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产品名称：
HCN-IN-1
目录号：
HY-186062
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