2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. HER2-targeted peptide H10

HER2-targeted peptide H10 是一种 HER2 靶向肽， Kd 值为 3.04 × 10-8 M。HER2-targeted peptide H10 与纳米颗粒偶联时可在异种移植小鼠的 HER2 阳性肿瘤组织中特异性聚集。HER2-targeted peptide H10 可用于 HER2 阳性乳腺癌的相关研究。

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HER2-targeted peptide H10

HER2-targeted peptide H10 Chemical Structure

CAS No. : 1802710-54-8

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HER2-targeted peptide H10 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HER2-targeted peptide H10 is a HER2-targeting peptide with a Kd value of 3.04 × 10-8 M. HER2-targeted peptide H10 specifically accumulates in HER2-positive tumor tissues of xenograft mice, when conjugated with nanoparticles. HER2-targeted peptide H10 can be used for studies related to HER2-positive breast cancer[1].

体外研究
(In Vitro)

HER2-targeted peptide H10 (H10) (5.0 × 10-5 M; 30 min at 4 °C) 可特异性结合高表达 HER2 的 SKBR-3 细胞，而不结合低表达 HER2 的 293A 细胞；在 HER2 表达下调的 SKBR-3 细胞中，该结合作用完全消失[1]。
HER2-targeted peptide H10 (0.1-100 μM) 表现出低细胞毒性，在受试细胞中，0.1 μM 至 100 μM 的浓度范围内细胞存活率接近 100%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HER2-targeted peptide H10 相关抗体:

Immunofluorescence[1]

Cell Line: human breast cancer SKBR-3 cells, human embryonic kidney 293A cells, HER2-downregulated RNAi SKBR-3 cells
Concentration: 5.0 × 10-5 M (FITC-labeled H10); 1 mM (Hoechst 33342)
Incubation Time: 30 min (at 4 °C)
Result: Showed strong green fluorescence signal on the membrane of SKBR-3 cells, but no significant binding to 293A cells.
Drastically reduced green fluorescence signal in HER2-downregulated RNAi SKBR-3 cells.
Measured a 53.32% binding rate of FITC-H10 to SKBR-3 cells via flow cytometry.
体内研究
(In Vivo)

HER2-targeted peptide H10 (2 μM；静脉注射；单次) 偶联量子点在裸鼠的 HER2 阳性乳腺癌异种移植物中特异性聚集，与非靶向量子点相比，其肿瘤荧光强度高且生物分布良好[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice (8-week-old female)[1]
Dosage: 2 μM
Administration: i.v.; single dose
Result: Showed specific accumulation at the tumor site in in vivo imaging.
Confirmed high fluorescence intensity in tumor tissue, with relatively lower accumulation in liver and spleen compared to H6-Qdot705.
Reached quantitative ex vivo fluorescence intensity of ~65,000 ×106 photons/cm2/s in tumors.
分子量

1114.30

Formula

C50H83N17O12
CAS 号
Sequence

Lys-Leu-Arg-Leu-Glu-Trp-Asn-Arg
Sequence Shortening

KLRLEWNR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HER2-targeted peptide H10 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HER2-targeted peptide H101802710-54-8EGFREpidermal growth factor receptorErbB-1HER1nude miceHER2-positive tumor tissuesHER2293A cellsHER2-positive breast cancerSKBR-3 cellsHER2-targeting peptideInhibitorinhibitorinhibit

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