2. Metabolic Enzyme/Protease
  3. Indoleamine 2,3-Dioxygenase (IDO)
  4. IDO1-IN-33

IDO1-IN-33 (Compound YC-16) 是一种 IDO1 抑制剂 (对于 HeLa 细胞中 IDO1 的 IC50 为 0.18 μM)。IDO1-IN-33 可通过缓慢竞争性地从成熟全酶型 IDO1 中置换血红素、并快速结合至未成熟脱辅基 IDO1 的血红素结合位点，发挥脱辅基 IDO1 抑制剂的作用，且不会改变 IDO1 的表达水平。IDO1-IN-33 可用于肝细胞癌、非小细胞肺癌、三阴性乳腺癌、宫颈癌的研究。

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IDO1-IN-33

IDO1-IN-33 Chemical Structure

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IDO1-IN-33 相关抗体

Top Publications Citing Use of Products

查看 Indoleamine 2,3-Dioxygenase (IDO) 亚型特异性产品:

查看所有亚型
IDO1 IDO2 IDO

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IDO1-IN-33 (Compound YC-16) is a IDO1 inhibitor (with an IC50 of 0.18 μM for IDO1 in HeLa cells). IDO1-IN-33 acts as an apo-IDO1 inhibitor by slowly and competitively displacing heme from mature holo-IDO1 and rapidly binding to the heme-binding site of immature apo-IDO1, without altering the expression level of IDO1. IDO1-IN-33 can be used for the research of hepatocellular carcinoma, non-small cell lung cancer, triple-negative breast cancer, and cervical cancer[1].

IC50 & Target[1]

IDO1

0.18 μM (IC50)

体外研究
(In Vitro)

IDO1-IN-33 (0.5 μM) 可强效抑制 HeLa 细胞中的 IDO1 活性，其 IC50 为 0.18 ± 0.01 μM，且无显著细胞毒性[1]。
IDO1-IN-33 (48 h) 可强效抑制多种人类肿瘤细胞系 (HepG2、A549、MDA-MB-231) 中的 IDO1 活性，其对应的 IC50 值分别为 216.25 ± 12.8 nM、115.9 ± 1.13 nM 和 135.25 ± 12.37 nM，且无显著细胞毒性[1]。
IDO1-IN-33 (0.05-0.4 μM; 48 h) 不会在 HeLa 细胞中调控 IDO1 mRNA 的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IDO1-IN-33 相关抗体:
分子量

432.95

Formula

C25H25ClN4O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IDO1-IN-33 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IDO1-IN-33Indoleamine 2,3-Dioxygenase (IDO)human tumor cell linesHeLa cellshepatocellular carcinomacervical cancerapo-IDO1IDO1holo-IDO1hemetriple-negative breast cancernon-small cell lung cancerInhibitorinhibitorinhibit

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