2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. EGFR CDK Cytochrome P450
  4. IMP-Zn

IMP-Zn 是一种吡唑-腙类希夫碱锌(II)配合物。IMP-Zn 对人结直肠癌细胞具有显著的抗增殖活性，且阻滞细胞周期。IMP-Zn 对三种癌症相关蛋白靶点 EGFR 激酶 1M17、细胞色素 P450 3RUK、CDK 抑制剂 6GUE 显示出比游离配体 IMP 更强的结合亲和力。IMP-Zn 可用于结直肠癌的相关研究。

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IMP-Zn

IMP-Zn Chemical Structure

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IMP-Zn 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

查看 CDK 亚型特异性产品:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

查看 Cytochrome P450 亚型特异性产品:

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IMP-Zn is a pyrazole-hydrazone Schiff base zinc (II) complex. IMP-Zn exhibits significant antiproliferative activity against human colorectal cancer cells and induces cell cycle arrest. IMP-Zn shows stronger binding affinity than its free ligand IMP towards three cancer-related protein targets: EGFR kinase 1M17, cytochrome P450 3RUK, and CDK inhibitor 6GUE. IMP-Zn can be used in studies related to colorectal cancer[1].

体外研究
(In Vitro)

IMP-Zn (10-50 μM; 24-72 h) 可强效降低人结直肠癌 HCT116 细胞的活力，其 IC50 值分别为 28.62 μM (24 h)、24.56 μM (48 h) 和 24.28 μM (72 h)；而在 48 h 后浓度高达 50 μM 的条件下，对正常 HEK293 细胞无细胞毒性[1]。
IMP-Zn (10-24.56 μM; 12 d) 可剂量依赖性地抑制人结直肠癌 HCT116 细胞的克隆形成能力，同时降低克隆的数量与大小[1]。
IMP-Zn (24.56 μM; 48 h) 可诱导人结直肠癌 HCT116 细胞出现 SubG0 期细胞累积，提示其为凋亡相关的细胞死亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IMP-Zn 相关抗体:

Cell Viability Assay[1]

Cell Line: human colorectal carcinoma HCT116 cells, normal human embryonic kidney HEK293 cells
Concentration: 10, 20, 30, 40, 50 μM (HCT116 cells); 10, 20, 30, 40, 50 μM (HEK293 cells)
Incubation Time: 24, 48, 72 h (HCT116 cells); 48 h (HEK293 cells)
Result: Reduced HCT116 cell viability in a time- and dose-dependent manner, with IC50 values of 28.62 μM (24 h), 24.56 μM (48 h), and 24.28 μM (72 h).
Showed no significant effect on HEK293 cell viability at concentrations up to 50 μM after 48 h.

Cell Cycle Analysis[1]

Cell Line: human colorectal carcinoma HCT116 cells
Concentration: 24.56 μM
Incubation Time: 48 h
Result: Increased the percentage of HCT116 cells in the SubG0 phase to 20.51% compared to 5.86% in control cells.
分子量

441.62

Formula

C17H15Cl2N5OZn
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IMP-Zn 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IMP-ZnEGFRCDKCytochrome P450Epidermal growth factor receptorErbB-1HER1Cyclin dependent kinaseCYPscytochrome P450apoptosisnormal human embryonic kidney cellsHEK293colorectal carcinomaepidermal growth factor receptorcyclin-dependent kinase inhibitorHCT116SubG0 phasecolorectal carcinoma cellsInhibitorinhibitorinhibit

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