2. Cell Cycle/DNA Damage
  3. DNA Alkylator/Crosslinker
  4. IOB-82

IOB-82 是一种双功能烷化剂。IOB‑82 可引发明显的细胞核和细胞质改变，导致严重的染色单体和染色体畸变，并重塑染色体倍性。IOB-82 具有剂量依赖性的拟辐射效应，且对大鼠大型 A 型腹水细胞表现出选择性细胞毒性。IOB-82 可用于黑色素瘤源性肿瘤和白血病的研究。

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IOB-82

IOB-82 Chemical Structure

CAS No. : 5977-35-5

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IOB-82 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IOB-82 is a bifunctional alkylating agent. IOB‑82 induces marked nuclear and cytoplasmic alterations, elicits severe chromatid and chromosome aberrations, and remodels chromosome ploidy. IOB-82 exerts dose-dependent radiomimetic effects and preferentially cytotoxic to large A-type rat ascites cells. IOB-82 can be applied in the research of melanoma‑derived tumors and leukemia[1][2].

体外研究
(In Vitro)

IOB-82 (3.62 × 10-4, 3.62 × 10-3 μM/mL; 24 h) 可诱导 HR-18 大鼠腹水细胞产生浓度依赖性形态损伤，A 型大细胞受损程度均比 B 型细胞更严重[2]。
IOB-82 (3.62 × 10-4, 3.62 × 10-3 μM/mL; 24 h) 可对 HR-18 大鼠腹水细胞产生浓度依赖性的染色体结构和数量损伤，能清除多倍体细胞及染色体数目为 85-86 的细胞群，增加染色体数目为 41-49 的细胞[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IOB-82 相关抗体:
分子量

276.16

Formula

C12H15Cl2NO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IOB-82 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IOB-825977-35-5NSC-146171IOB82IOB 82NSC146171NSC 146171DNA Alkylator/Crosslinkernitrogen mustardalkylating agentHR-18 rat ascites cellssteroidal mustard esterA-type rat ascites cellschromosome aberrationschromatid aberrationsmelanocarcinomaB-type rat ascites cellsleukemia p388Inhibitorinhibitorinhibit

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目录号：
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