2. MAPK/ERK Pathway Stem Cell/Wnt Apoptosis
  3. ERK Ferroptosis
  4. JWG-045

JWG-045 是一种选择性的 ERK5 抑制剂。JWG-045 具有独立于 ERK5 抑制的、特有的、抗铁死亡 (ferroptosis) 活性。JWG-045 可用于乳腺癌的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

JWG-045

JWG-045 Chemical Structure

CAS No. : 1234480-61-5

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

JWG-045 相关抗体

Top Publications Citing Use of Products

查看 ERK 亚型特异性产品:

查看所有亚型
ERK ERK1 ERK2 ERK5 ERK8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JWG-045 is a selective ERK5 inhibitor. JWG-045 exhibits unique ferroptosis-resistant activity independent of ERK5 inhibition. JWG-045 can be used in breast cancer research[1].

IC50 & Target[1]

ERK5

 

体外研究
(In Vitro)

JWG-045 (3 μM; 24 h) 可轻度降低 BT474 细胞的细胞密度，并可保护 BT474 和 MDA-MB-231 乳腺癌细胞免受 RSL3 诱导的铁死亡[1]。
JWG-045 (3 μM; 24 h) 可保护 ERK5 沉默的 MDA-MB-231 三阴性乳腺癌细胞免受 RSL3 诱导的铁死亡，且该作用独立于 ERK5 的表达[1]。
JWG-045 (3 μM; 6 days) 可降低 Trastuzumab (HY-P9907) 耐药性 BT474 乳腺癌细胞的细胞密度，并恢复其对 Trastuzumab 的敏感性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JWG-045 相关抗体:

Cell Viability Assay[1]

Cell Line: BT474 luminal B breast cancer cells, MDA-MB-231 triple-negative breast cancer cells
Concentration: 3 μM (single treatment; pre-incubated then combined with RSL3)
Incubation Time: 24 h (single treatment; total incubation with RSL3); 20 h (live-cell imaging)
Result: Caused a modest, statistically significant reduction in BT474 cell density.
Reduced RSL3-induced cytotoxicity in both BT474 and MDA-MB-231 cells, significantly increasing cell density compared to RSL3 alone.
Prevented the time-dependent decrease in BT474 cell confluency induced by RSL3 over 20 hours.

Cell Viability Assay[1]

Cell Line: ERK5-silenced MDA-MB-231 triple-negative breast cancer cells
Concentration: 3 μM (alone; combined with RSL3)
Incubation Time: 24 h
Result: Blocked RSL3-induced ferroptotic death in both control and ERK5-silenced MDA-MB-231 cells, significantly increasing cell density compared to RSL3 alone.

Cell Proliferation Assay[1]

Cell Line: Trastuzumab-resistant BT474 breast cancer cells
Concentration: 3 μM (alone; combined with Trastuzumab)
Incubation Time: 6 days
Result: Reduced BT474 cell density.
Restored the growth inhibitory effect of trastuzumab in Trastuzumab-resistant BT474 cells to the level achieved by Trastuzumab monotherapy in parental BT474 cells.
分子量

487.60

Formula

C27H33N7O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JWG-045 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JWG-0451234480-61-5JWG045JWG 045ERKFerroptosisExtracellular signal regulated kinasesferroptosisMDA-MB-231 breast cancer cellsBRD4SUM159PT triple-negative breast cancer cellsLRRK2HeLa cervical cancer cellsbreast cancer cellsERK5DCLKBT474 cellsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
JWG-045
目录号：
HY-181968
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z