2. PROTAC Others Metabolic Enzyme/Protease
  3. Molecular Glues Drug Derivative E1/E2/E3 Enzyme
  4. JWZ-8-103

JWZ-8-103 是一种具有口服活性的 PRLX-93936 (HY-119264) 类似物，也是一种靶向 TRIM21 的分子胶 (molecular glue)。JWZ-8-103 可提高 TRIM21 的热稳定性。JWZ-8-103 可促进 TRIM21 和 NUP98 之间快速而有效的相互作用 (和 TRIM21 PRYSPRY 和 NUP98 APD 形成三元复合物的表观 EC50 约为 20 μM)。JWZ-8-103 对胰腺癌具有抗癌作用。

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JWZ-8-103

JWZ-8-103 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥2160
2 - 4 周
5 mg ￥5310
2 - 4 周
10 mg 询价 2 - 4 周
25 mg 询价 2 - 4 周
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

JWZ-8-103 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JWZ-8-103 is an orally active PRLX-93936 (HY-119264) analog and TRIM21-targeting molecular glue. JWZ-8-103 increases the thermal stability of TRIM21. JWZ-8-103 promotes a robust and rapid interaction between TRIM21 and NUP98 (apparent EC50 = ∼20 μM for TRIM21 PRYSPRY and NUP98 APD). JWZ-8-103 has anti-cancer effects against pancreatic cancer[1][2].

IC50 & Target

apparent EC50 = ∼20 μM (ternary complex formation between TRIM21 PRYSPRY and NUP98 APD in the presence of JWZ-8-103)[1]
分子量

416.88

Formula

C21H22ClFN4O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JWZ-8-103 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JWZ-8-103Molecular GluesDrug DerivativeE1/E2/E3 EnzymeDrug derivativeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseanti-cancerpancreatic cancerInhibitorinhibitorinhibit

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目录号：
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