2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Kojic amine

Kojic amine 是一种具有口服活性的 γ- 氨基丁酸 (GABA) 类似物。Kojic amine 可作为 GABA 模拟剂，能够抑制大鼠脑细胞膜上不依赖钠离子的 [3H]GABA 结合。Kojic amine 可减轻慢性脊髓大鼠和猫模型中的屈肌痉挛。Kojic amine 可预防小鼠强直性伸肌惊厥。Kojic amine 在小鼠热板试验中可产生短暂的、剂量依赖性镇痛作用。Kojic amine 可用于骨骼肌痉挛、癫痫、镇痛的相关研究。

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Kojic amine

Kojic amine Chemical Structure

CAS No. : 68642-64-8

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Kojic amine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Kojic amine is an orally active γ-aminobutyric acid (GABA) analog. Kojic amine acts as a GABA mimic that inhibits sodium-independent [3H]GABA binding to rat brain cell membranes. Kojic amine reduces flexor spasms in chronic spinal rat and cat models. Kojic amine prevents tonic extensor convulsions in mice. Kojic amine produces a transient, dose-dependent analgesic effect in the mouse hot-plate test. Kojic amine can be used in research related to skeletal muscle spasm, epilepsy and analgesia[1][2]

体外研究
(In Vitro)

Kojic amine (Compound 3) 可强效且特异性地抑制不依赖钠离子的 [3H]GABA 与大鼠脑细胞膜的结合[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Kojic amine 相关抗体:
体内研究
(In Vivo)

Kojic amine (静脉注射) 可使慢性脊髓大鼠的屈肌反射痉挛减少 70%，其静脉给药的 ED70 为 8 mg/kg[1]。
Kojic amine (静脉注射、口服；累积给药) 可使慢性脊髓猫的屈肌反射痉挛减轻 70%，其静脉给药 ED70 为 2.2 mg/kg，口服 ED70 为 4 mg/kg[1]。
Kojic amine (15-128 mg/kg；灌胃；单次给药) 可在口服 ED50 为 15 mg/kg 的剂量下，预防 50%的小鼠发生 3-巯基丙酸诱导的强直性伸肌惊厥[1]。
Kojic amine (8.2-15.7 mg/kg；腹腔注射,；一次) 在 48°C 、55°C 小鼠热板试验中可产生剂量依赖性、短效镇痛作用，ED50 分别为 9.2、13.8 mg/kg[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Robidoux Swiss (male, 18-22 g, 3-mercaptopropionic acid-induced convulsions)[1]
Dosage: 15 mg/kg (seizure prevention ED50); 128 mg/kg (acute oral non-lethal)
Administration: p.o.; single dose (30 mins prior to convulsion induction)
Result: Prevented tonic extensor seizures in 50% of mice (ED50) challenged with 3-mercaptopropionic acid.
Allowed all mice to survive an acute oral dose of 128 mg/kg.
Animal Model: albino Swiss CD-1 (male, 18-24 g)[2]
Dosage: 8.2-15.7 mg/kg
Administration: i.p.; single dose
Result: Produced dose-dependent, short-acting analgesic effects in the mouse hot-plate test at 48°C and 55°C, with ED50 values of 9.2 mg/kg and 13.8 mg/kg, respectively.
分子量

141.13

Formula

C6H7NO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Kojic amine 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kojic amine68642-64-8GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorGABA receptor3-mercaptopropionic acidrat brain membranescerebellar Purkinje cellGABA_B receptormiceskeletal muscle relaxantGABA_A receptorchronic spinal ratchronic spinal catskeletal muscle spasmepilepsy and analgesiaInhibitorinhibitorinhibit

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