2. Cell Cycle/DNA Damage
  3. p97
  4. LC-1028

LC-1028 (Compound 20) 是一种不可逆的、非竞争性的、共价的 p97 抑制剂，Kiapp 值为 33.2 nM。LC-1028 可共价修饰 p97 的半胱氨酸残基 (Cys105、Cys522、Cys535)，破坏 p97 活性。LC-1028 可用于胰腺癌的研究。

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LC-1028

LC-1028 Chemical Structure

CAS No. : 2324158-08-7

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LC-1028 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LC-1028 (Compound 20) is an irreversible, non-competitive, covalent p97 inhibitor with a Kiapp value of 33.2 nM. LC-1028 covalently modifies the cysteine residues (Cys105, Cys522, Cys535) of p97 and impairs p97 activity. LC-1028 can be used in the research of pancreatic cancer[1].

体外研究
(In Vitro)

LC-1028 (20 min) 可不可逆地抑制纯化的野生型 p97 酶活性，其表观抑制常数 Kiapp 为 33.2 nM[1]。
LC-1028 (1 μM) 可与 GSH 发生共价反应，半衰期为 16.4 h，形成可检测到的加合物[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LC-1028 相关抗体:

Western Blot Analysis[1]

Cell Line: A373 cells stably expressing US11 and HA-tagged MHC class I heavy chain
Concentration: 2 μM
Incubation Time: 1 h treatment, followed by 0-3 h chase in inhibitor-free medium
Result: Caused a drastically reduced rate of MHC class I heavy chain turnover after agent washout compared to cells treated with the reversible p97 inhibitor NMS-873.
分子量

449.55

Formula

C28H27N5O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LC-1028 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LC-10282324158-08-7LC1028LC 1028p97VCPCdc48Cys522pancreatic cancer cellsMIA PaCa-2ATPase activityUb-v-GFPCys105A373 cellsHEK293T cellsCys535Inhibitorinhibitorinhibit

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