2. Protein Tyrosine Kinase/RTK Immunology/Inflammation
  3. Src Interleukin Related
  4. LDDN-0003499

LDDN-0003499 是一种 Src 家族酪氨酸激酶抑制剂及抗炎剂。LDDN-0003499 可降低小胶质细胞中基础状态及 Aβ 刺激下的活化型磷酸化 Lyn 和 Src 激酶水平，并减弱 Aβ 刺激促炎细胞因子 TNFα 和 IL-6 的分泌。LDDN-0003499 可用于阿尔茨海默病的相关研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

LDDN-0003499

LDDN-0003499 Chemical Structure

CAS No. : 331662-51-2

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

LDDN-0003499 相关抗体

Top Publications Citing Use of Products

查看 Src 亚型特异性产品:

查看所有亚型
Lck Fyn Blk Fgr Hck Lyn Yes SRC-3

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LDDN-0003499 is a Src family tyrosine kinase inhibitor and anti-inflammatory agent. LDDN-0003499 reduces basal and Aβ-stimulated levels of active, phosphorylated Lyn and Src kinases, and attenuates Aβ-stimulated secretion of pro-inflammatory cytokines TNFα and IL-6 in microglial cells. LDDN-0003499 can be used for the research of Alzheimer's disease[1].

IC50 & Target[1]

IL-6

 

体外研究
(In Vitro)

LDDN-0003499 (0.5 nM-50 μM; 24 h) 对小鼠小胶质细胞 BV2 无毒性[1]。
LDDN-0003499 (0.5 nM-50 μM; 1 h) 可剂量依赖性地降低小鼠小胶质细胞 BV2 中的总蛋白磷酸酪氨酸水平[1]。
LDDN-0003499 (0.5 nM-50 μM; 1 h) 可剂量依赖性地抑制小鼠小胶质细胞 BV2 中基础活性的磷酸化 Lyn 和 Src 水平[1]。
LDDN-0003499 (0.5 nM-50 μM；65 min) 可在小鼠小胶质细胞 BV2 中呈剂量依赖性地抑制 Aβ 诱导的活化磷酸化 Lyn 和 Src 水平升高[1]。
LDDN-0003499 (0.5 nM-50 μM; 1 h) 可呈剂量依赖性降低小鼠小胶质细胞 BV2 中 Aβ 刺激诱导的 TNF-α 和 IL-6 分泌[1]。
LDDN-0003499 (1 μM) 在人源和小鼠肝微粒体中表现出中等偏高的 NADPH 依赖性清除率和较低的非 NADPH 依赖性清除率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LDDN-0003499 相关抗体:

Western Blot Analysis[1]

Cell Line: unstimulated murine microglial BV2 cells
Concentration: 0.5 nM, 5 nM, 50 nM, 0.5 μM, 5 μM, 50 μM
Incubation Time: 1 h
Result: Produced a dose-dependent decrease in active, phosphorylated Lyn (pLyn) and Src (pSrc) protein levels.
Did not alter phosphorylated levels of ERK, JNK, or p38.

Western Blot Analysis[1]

Cell Line: Aβ-stimulated murine microglial BV2 cells
Concentration: 0.5 nM, 5 nM, 50 nM, 0.5 μM, 5 μM, 50 μM
Incubation Time: 1 h (pre-incubation); 5 min (co-incubation with 1 μM Aβ1-42)
Result: Attenuated the Aβ-stimulated increase in active, phosphorylated Lyn and Src protein levels.
Significantly attenuated the Aβ-stimulated increase in pLyn at 50 nM, while 500 nM was required for pSrc, demonstrating 10-fold selectivity for Lyn over Src in this paradigm.
Did not inhibit Aβ-stimulated increases in phosphorylated ERK.
分子量

350.20

Formula

C16H13Cl2N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LDDN-0003499 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LDDN-0003499331662-51-2LDDN0003499LDDN 0003499SrcInterleukin RelatedILLyn kinasesERKIL-6Src family tyrosine kinaseSrc kinasesmicroglial cellsJNKmurine microglial BV2 cellsAlzheimer's diseaseTNFαInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
LDDN-0003499
目录号：
HY-112369
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z