2. Epigenetics
  3. Histone Methyltransferase
  4. LLC0424N

LLC0424N 是一种通过甲基化 LLC0424 (HY-161574) 的沙利度胺母核设计得到的阴性对照化合物。LLC0424N 不会诱导 NSD2 降解，也不会抑制携带 NSD2 突变的急性淋巴细胞白血病细胞的增殖。LLC0424N 可用于急性淋巴细胞白血病的相关研究。

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LLC0424N

LLC0424N Chemical Structure

CAS No. : 3063448-59-6

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Other Forms of LLC0424N:

LLC0424N 相关抗体

Top Publications Citing Use of Products

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 NSD3/WHSC1L1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LLC0424N is a negative control compound designed by methylating the thalidomide moiety of LLC0424 (HY-161574). LLC0424N shows does not induce NSD2 degradation and inhibit growth of acute lymphoblastic leukemia cells with NSD2 mutation. LLC0424N can be used for the research of acute lymphoblastic leukemia[1].

体外研究
(In Vitro)

LLC0424N (0.5-2 μM; 12-24 h) 在 SEM ALL 细胞中无法高效降解 NSD2 蛋白[1]。
LLC0424N (2 μM; 8-24 h) 不会下调 SEM ALL 和 RPMI-8402 细胞中 NSD2 或 H3K36me2 的蛋白水平[1] 。
LLC0424N (100 nM-30 μM; 7 days) 不呈剂量依赖性抑制 SEM ALL 和 RPMI-8402 细胞的生长[1]。
LLC0424N (2 μM; 30 days) 不会降低 RPMI-8402 急性淋巴细胞白血病 (ALL) 细胞的集落形成能力或集落大小[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LLC0424N 相关抗体:

Western Blot Analysis[1]

Cell Line: SEM acute lymphoblastic leukemia (ALL) cells with NSD2 E1099K gain-of-function mutation
Concentration: 0.5, 2 μM
Incubation Time: 12, 24 h
Result: Maintained NSD2 protein levels near 100% of control levels.
分子量

837.88

Formula

C46H43N7O9
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LLC0424N 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LLC0424N3063448-59-6Histone MethyltransferaseSEM ALL cellsRPMI-8402 ALL cellsH3K36me2acute lymphoblastic leukemiaNSD2Inhibitorinhibitorinhibit

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产品名称：
LLC0424N
目录号：
HY-185557
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