2. Academic Validation
  3. Pyrazole-O-glucosides as novel Na(+)-glucose cotransporter (SGLT) inhibitors

Pyrazole-O-glucosides as novel Na(+)-glucose cotransporter (SGLT) inhibitors

  • Bioorg Med Chem Lett. 2003 Jul 21;13(14):2269-72. doi: 10.1016/s0960-894x(03)00466-9.
Koji Ohsumi 1,  Hiroyuki Matsueda,  Toshihiro Hatanaka,  Ryusuke Hirama,  Takashi Umemura,  Akiko Oonuki,  Nozomu Ishida,  Yoko Kageyama,  Katsumi Maezono,  Nobuo Kondo
Affiliations

Affiliation

  • 1 Pharmaceutical Research Laboratories, Pharmaceutical Company, Ajinomoto Co., Inc., 1-1, Suzuki-cho, Kawasaki-ku, 210-8681, Kawasaki, Japan. koji_ohsumi@ajinomoto.com
PMID: 12824015 DOI: 10.1016/s0960-894x(03)00466-9
Abstract

O-glucuronides and O-glucosides of a series of pyrazoles analogues were synthesized and evaluated for their SGLT inhibitory activity in brush border membrane vehicles (BBMVs) of rat kidney. O-glucosides of certain pyrazole analogues inhibited the transport of [(14)C]-glucose in BBMVs, and induced glucosuria in Wistar rats by intravenous injection.

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