2. Academic Validation
  3. Bioactive triterpene saponins from the roots of Phytolacca americana

Bioactive triterpene saponins from the roots of Phytolacca americana

  • J Nat Prod. 2008 Jan;71(1):35-40. doi: 10.1021/np078012m.
Liyan Wang 1,  Liming Bai,  Takashi Nagasawa,  Toshiaki Hasegawa,  Xiaoyang Yang,  Jun-ichi Sakai,  Yuhua Bai,  Takao Kataoka,  Seiko Oka,  Katsutoshi Hirose,  Akihiro Tomida,  Takashi Tsuruo,  Masayoshi Ando
Affiliations

Affiliation

  • 1 Graduate School of Science and Technology, Department of Chemistry and Chemical Engineering, Niigata University, Japan. wlydlm@yahoo.co.jp
PMID: 18177012 DOI: 10.1021/np078012m
Abstract

Five new triterpene saponins named phytolaccasaponins N-1 (1), N-2 (2), N-3 (3) N-4 (4), and N-5 (5) were isolated from the roots of Phytolacca americana together with seven known triterpene saponins (6-12). The structures of the five new saponins were established as shown in structures 1-5 on the basis of their spectroscopic data. The MDR-reversal activity of 1-12 was evaluated on the basis of the amount of calcein accumulated in MDR human ovarian Cancer 2780 AD cells in the presence of each compound. The most effective compound was 8 (155% of control at 25 microg/mL).

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