2. Academic Validation
  3. Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M

Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M

  • Angew Chem Int Ed Engl. 2011 Oct 10;50(42):9838-42. doi: 10.1002/anie.201102967.
Marion Rusch 1,  Tobias J Zimmermann,  Marco Bürger,  Frank J Dekker,  Kristina Görmer,  Gemma Triola,  Andreas Brockmeyer,  Petra Janning,  Thomas Böttcher,  Stephan A Sieber,  Ingrid R Vetter,  Christian Hedberg,  Herbert Waldmann
Affiliations

Affiliation

  • 1 Max-Planck-Institut für Molekulare Physiologie, Abt. Chemische Biologie, Dortmund, Germany.
PMID: 21905186 DOI: 10.1002/anie.201102967
Abstract

Finding the target: activity-based proteomic profiling probes based on the depalmitoylation inhibitors palmostatin B and M have been synthesized and were found to target acyl protein thioesterase 1 (APT1) and 2 (APT2) in cells.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-152951
    Ras信号调节剂
    Ras
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