2. Academic Validation
  3. Antibacterial steroidal alkaloids from Holarrhena antidysenteriaca

Antibacterial steroidal alkaloids from Holarrhena antidysenteriaca

  • Chin J Nat Med. 2017 Jul;15(7):540-545. doi: 10.1016/S1875-5364(17)30080-8.
Li-Na Zhou 1,  Xiao-Lei Ge 2,  Ting-Ting Dong 2,  Hui-Yuan Gao 2,  Bo-Hang Sun 3
Affiliations

Affiliations

  • 1 School of Life Science and Biopharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • 2 School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • 3 School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: sunbohang1978@163.com.
PMID: 28807228 DOI: 10.1016/S1875-5364(17)30080-8
Abstract

Two new steroidal Alkaloids, isoconkuressine and N-formylconessimine, together with 6 known steroidal Alkaloids including conkuressine, conessine, isoconessimine, conimine, conarrhimine, and funtudienine, were isolated from the seeds of Holarrhena antidysenteriaca Wall.ex A.DC. Their intrinsic Antibacterial activities and synergistic effects with penicillin and vancomycin were analyzed in methicillin sensitive staphylococcus aureus (MSSA) and methicillin resistant staphylococcus aureus (MRSA). Two of the steroidal Alkaloids including one new compound (N-formylconessimine) showed potential Antibacterial activity and possessed synergistic effects with penicillin and vancomycin, respectively.

Keywords

Antibacterial; Holarrhena antidysenteriaca; MRSA; MSSA; Steroidal alkaloid; Synergistic effect.

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