2. Academic Validation
  3. Isoprenylated flavonoids from Morus nigra and their PPAR γ agonistic activities

Isoprenylated flavonoids from Morus nigra and their PPAR γ agonistic activities

  • Fitoterapia. 2018 Jun:127:109-114. doi: 10.1016/j.fitote.2018.02.004.
Liang-Jin Xu 1,  Mei-Hua Yu 2,  Chun-Yue Huang 1,  Li-Xin Niu 1,  Yi-Fan Wang 3,  Chun-Zhen Wu 1,  Pei-Ming Yang 1,  Xiao Hu 4
Affiliations

Affiliations

  • 1 Innovation Center of Chinese Medicine, China State Institute of Pharmaceutical Industry, Shanghai 201203, China.
  • 2 Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, China.
  • 3 Innovation Center of Chinese Medicine, China State Institute of Pharmaceutical Industry, Shanghai 201203, China; Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, China.
  • 4 Innovation Center of Chinese Medicine, China State Institute of Pharmaceutical Industry, Shanghai 201203, China. Electronic address: xjtuyxhx@126.com.
PMID: 29427594 DOI: 10.1016/j.fitote.2018.02.004
Abstract

A novel dihydroflavonol unprecedentedly with a prenyl group at C-2, nigragenon A (1), four new sanggenon-type Flavonones, nigragenons B-E (2-5), along with six known isoprenylated Flavonoids (6-11) were isolated from the twigs of Morus nigra. Their structures were elucidated through extensive analysis of spectroscopic data. Interestingly, compound 1 was the first reported biogenetic precursor of sanggenon-type flavanones and the biogenetic pathway from 1 to sanggenol F was proposed. The PPAR γ agonistic activity was investigated in HEK293 cells using dual luciferase reporter assay. Compounds 2, 4, 7, and 9 showed obvious agonistic activities on PPAR γ, and compound 2 was a potential PPAR γ partial agonist. Moreover, the preliminary structure-activity relationships for the tested compounds were discussed.

Keywords

Agonistic activity; Moraceae; Morus nigra; PPAR γ; Sanggenon-type flavonones.

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