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  3. Drug Derivative
  4. Sanggenol F

Sanggenol F 是一种天然的酚类化合物。

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Sanggenol F

Sanggenol F Chemical Structure

CAS No. : 202526-51-0

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Sanggenol F 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sanggenol F is a natural phenolic compound.

IC50 & Target[1]

α‑glucosidase

12.39 μM (IC50)

PPARγ

 

体外研究
(In Vitro)

Sanggenol F (2.5-10 μM；8 天) 可促进 3T3-L1 前脂肪细胞的脂肪细胞分化 [1]。
Sanggenol F (1.25-10 μM；8天) 可增强分化的 3T3-L1 脂肪细胞的葡萄糖摄取[1]。
Sanggenol F (10 μM；0-8 h) 可在成熟 3T3-L1 脂肪细胞中刺激 P-AKT 的表达[1]。
Sanggenol F (0.625-30 μM；18-24 h) 可激活 HEK293T 细胞中 PPARγ 的转录活性[1][2]。
Sanggenol F (1.25-20 μM；30 min) 以浓度依赖的方式抑制 PTP1B 活性[1]。
Sanggenol F (2.5-10 μM；1-8 天) 可调节 3T3-L1 细胞中脂肪因子和脂肪生成基因的表达 [1]。
Sanggenol F 抑制 α- 葡萄糖苷酶，IC50 为 12.39 μM[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sanggenol F 相关抗体:

Western Blot Analysis[1]

Cell Line: Mature 3T3-L1 adipocytes
Concentration: 10 μM
Incubation Time: 0, 2, 5, 10, 30 min, 1, 2, 4, 8 h
Result: Stimulated P-AKT expression over the indicated time points

Real Time qPCR[1]

Cell Line: 3T3-L1 cells
Concentration: 2.5, 5, 10 μM
Incubation Time: 1-8 days
Result: Upregulated mRNA levels of adiponectin, visfatin, SREBP1c, ACC1, FAS, GPAT, DGAT1, DGAT2.
Downregulated MCP1 mRNA.
Upregulated C/EBPβ and PPARγ mRNA over Days 1-3 at 2.5 and 5 μM.
体内研究
(In Vivo)

桑根酚 F (8-30 mg/kg；腹腔注射；每日一次；连续 28 天) 可改善 2 型糖尿病雄性 C57BL/KsJ-db/db 小鼠的糖代谢、胰岛素敏感性、脂质代谢及肝脏脂肪变性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/KsJ-db/db (male, 6-week-old)[1]
Dosage: 8, 30 mg/kg
Administration: i.p.; daily; 28 days
Result: Decreased fasting blood glucose and serum insulin content.
Improved glucose tolerance with reduced OGTT AUC and improved insulin sensitivity with reduced ITT AUC.
Decreased serum triglyceride and free fatty acid levels.
Upregulated lipogenic genes (ACC1, FAS, GLUT4, PPARγ) in epididymal white adipose tissue and inguinal white adipose tissue.
Downregulated inflammatory adipokines (MCP1, IL-6, IL-1β) and monocyte/macrophage markers (CD11b, CD11c, F4/80) in epididymal white adipose tissue and inguinal white adipose tissue.
Upregulated adiponectin in epididymal white adipose tissue and inguinal white adipose tissue.
Increased hepatic p-AKT expression.
Suppressed hepatic gluconeogenic genes (G6PC, PCK1) and glycogenolytic gene (PYGL).
Reduced hepatic triglyceride content and ameliorated hepatic steatosis.
分子量

438.47

Formula

C25H26O7
CAS 号
中文名称

桑根醇F
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Sanggenol F 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sanggenol F202526-51-0桑根醇FDrug DerivativeDrug derivativeinsulinPPARγsteatosis3T3-L1 adipocytesPPARαC57BL/KsJ-db/db miceadipokinelipid levelstype 2 diabetesP-AKTPTP1Bfasting blood glucoseHEK293T cellsInhibitorinhibitorinhibit

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目录号：
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