2. Academic Validation
  3. Small-Molecule Inhibition of Glucose Transporters GLUT-1-4

Small-Molecule Inhibition of Glucose Transporters GLUT-1-4

  • Chembiochem. 2020 Jan 15;21(1-2):45-52. doi: 10.1002/cbic.201900544.
Elena S Reckzeh 1 2,  Herbert Waldmann 1 2
Affiliations

Affiliations

  • 1 Department Chemical Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.
  • 2 Department Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227, Dortmund, Germany.
PMID: 31553512 DOI: 10.1002/cbic.201900544
Abstract

Glucose addiction is observed in Cancer and Other Diseases that are associated with hyperproliferation. The development of compounds that restrict glucose supply and decrease glycolysis has great potential for the development of new therapeutic approaches. Addressing facilitative glucose transporters (GLUTs), which are often upregulated in glucose-dependent cells, is therefore of particular interest. This article reviews a selection of potent, isoform-selective GLUT inhibitors and their biological characterization. Potential therapeutic applications of GLUT inhibitors in oncology and Other Diseases that are linked to glucose addiction are discussed.

Keywords

GLUT inhibitors; antitumor agents; cancer; drug discovery; metabolism.

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