2. PI3K/Akt/mTOR Membrane Transporter/Ion Channel
  3. mTOR GLUT
  4. NV-5440

NV-5440 (Compound I-120) 是一种 mTORC1 抑制剂和葡萄糖转运蛋白 (glucose transporter) 抑制剂。NV-5440 靶向 GLUT-1、-2、-3 和-4，且对 GLUT-5 无活性。NV-5440 可抑制葡萄糖摄取。

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NV-5440

NV-5440 Chemical Structure

CAS No. : 2226614-88-4

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Customer Review

NV-5440 相关抗体

Top Publications Citing Use of Products

查看 mTOR 亚型特异性产品:

查看所有亚型
mTOR mTORC1 mTORC2

查看 GLUT 亚型特异性产品:

查看所有亚型
GLUT1 GLUT2 GLUT3 GLUT4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NV-5440 (Compound I-120) is an mTORC1 inhibitor and glucose transporter inhibitor. NV-5440 targets GLUT-1, -2, -3, and -4, and shows no activity against GLUT-5. NV-5440 inhibits glucose uptake[1][2].

IC50 & Target[1]

mTORC1

 

GLUT1

 

GLUT2

 

GLUT3

 

GLUT4

 

体外研究
(In Vitro)

NV-5440 可强效抑制 MCF7 细胞中 3H-2DG 的摄取，IC50 为 36 nM，其作用靶点涵盖 GLUT-1 至 GLUT-4，但不包括 GLUT-5[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NV-5440 相关抗体:
体内研究
(In Vivo)

NV-5440 (30 mg/kg；腹腔注射) 可抑制小鼠体内的 mTORC1 活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[2]
Dosage: 30 mg/kg
Administration: i.p.
Result: Confirmed inhibition of
mTORC1 activity.
分子量

572.73

Formula

C31H36N6O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NV-5440 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NV-54402226614-88-4NV5440NV 5440mTORGLUTMammalian target of RapamycinGlucose transporterMCF7 cellsmTORC1GLUT-3glucose transporter inhibitorGLUT-1GLUT-2GLUT-4mTORC1 inhibitorGLUT-5Inhibitorinhibitorinhibit

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