2. Academic Validation
  3. Antifungal activities of metconazole against the emerging wheat pathogen Fusarium pseudograminearum

Antifungal activities of metconazole against the emerging wheat pathogen Fusarium pseudograminearum

  • Pestic Biochem Physiol. 2023 Feb:190:105298. doi: 10.1016/j.pestbp.2022.105298.
Xin Liu 1,  Shuang Wang 1,  Zhongyue Fan 2,  Jiawen Wu 3,  Liwen Wang 1,  Dan He 4,  Sherif Ramzy Mohamed 5,  Dawood H Dawood 6,  Jianrong Shi 1,  Tao Gao 7,  Jianhong Xu 8
Affiliations

Affiliations

  • 1 School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, Jiangsu, PR China; Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base, Ministry of Science and Technology/Key Laboratory for Control Technology and Standard for Agro-product Safety and Quality, Ministry of Agriculture and Rural Affairs/Key Laboratory for Agro-product Safety Risk Evaluation (Nanjing), Ministry of Agriculture and Rural Affairs/Collaborative Innovation Center for Modern Grain Circulation and Safety/Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, Jiangsu, PR China.
  • 2 College of Life Science, Sanquan College of Xinxiang Medical University, Xinxiang 453003, Henan, PR China.
  • 3 Jiangsu Plant Protection and Plant Quarantine Station, Nanjing 210036, Jiangsu, PR China.
  • 4 Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base, Ministry of Science and Technology/Key Laboratory for Control Technology and Standard for Agro-product Safety and Quality, Ministry of Agriculture and Rural Affairs/Key Laboratory for Agro-product Safety Risk Evaluation (Nanjing), Ministry of Agriculture and Rural Affairs/Collaborative Innovation Center for Modern Grain Circulation and Safety/Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, Jiangsu, PR China.
  • 5 Food Toxicology and Contaminants Dept., National Research Centre, Egypt, Giza 12411, Egypt.
  • 6 Department of Agriculture Chemistry, Faculty of Agriculture, Mansoura University, Mansoura 35516, Egypt.
  • 7 Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base, Ministry of Science and Technology/Key Laboratory for Control Technology and Standard for Agro-product Safety and Quality, Ministry of Agriculture and Rural Affairs/Key Laboratory for Agro-product Safety Risk Evaluation (Nanjing), Ministry of Agriculture and Rural Affairs/Collaborative Innovation Center for Modern Grain Circulation and Safety/Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, Jiangsu, PR China. Electronic address: gaotao8806@jaas.ac.cn.
  • 8 School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, Jiangsu, PR China; Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base, Ministry of Science and Technology/Key Laboratory for Control Technology and Standard for Agro-product Safety and Quality, Ministry of Agriculture and Rural Affairs/Key Laboratory for Agro-product Safety Risk Evaluation (Nanjing), Ministry of Agriculture and Rural Affairs/Collaborative Innovation Center for Modern Grain Circulation and Safety/Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, Jiangsu, PR China. Electronic address: xujianhongnj@126.com.
PMID: 36740330 DOI: 10.1016/j.pestbp.2022.105298
Abstract

Fusarium crown rot of wheat is a serious Fungal disease that occurs worldwide. The disease has been emerging in the major wheat-growing areas in China since 2010. Fusarium pseudogramineaum is the predominant causative pathogen of crown rot of wheat in China. The 14α-demethylation inhibitor (DMI) fungicide metconazole has been shown to be effective against Fusarium spp., but little is known about its specific activity against F. pseudogramineaum. Metconazole exhibited strong Antifungal activities against all thirty-nine F. pseudogramineaum strains collected from the major wheat-growing areas in China. Metconazole inhibited mycelial growth and conidial germ tube elongation of F. pseudograminearum. Metconazole treatment significantly reduced the production of major toxins and the expression levels of toxin biosynthesis genes. Genome-wide transcriptional profiling of F. pseudograminearum in response to metconazole indicated that the expression of genes involved in ergosterol biosynthesis, including fungicide target genes (CYP51 genes), was significantly induced by metconazole. Nine ATP-binding cassette (ABC) transporter-encoding genes were significantly expressed in response to metconazole treatment. Reduced ergosterol production and antioxidant enzyme activities were observed after metconazole treatment. Greenhouse experiments indicated a significant reduction in crown rot occurrence in wheat after seed treatment with metconazole. This study evaluated the potential of metconazole to manage wheat crown rot and provides information to understand its Antifungal activities and mechanism of action against F. pseudograminearum.

Keywords

Control efficacy; Fusarium crown rot; Fusarium pseudograminearum; Metconazole; RNA-Seq; Sensitivity.

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