2. Academic Validation
  3. Inhibition of fumarase by S-2,3-dicarboxyaziridine

Inhibition of fumarase by S-2,3-dicarboxyaziridine

  • J Biol Chem. 1985 Jun 10;260(11):6684-6.
J Greenhut,  H Umezawa,  F B Rudolph
PMID: 3997845
Abstract

S-2,3-Dicarboxyaziridine was found to be a potent competitive inhibitor (Ki = 0.08 microM) of fumarase from pig heart. The aziridine did not inactivate the enzyme or exhibit any observable substrate activity. It is likely that it functions as a transition state analogue mimicking the carbanion intermediate found in the normal catalytic reaction. The aziridine inhibited fumarate utilization in ruptured but not intact mitochondria.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z