2. Academic Validation
  3. Marine fungal-derived butyrolactone attenuates intestinal inflammation through MAPK/NF-κB and NLRP3 signaling pathway

Marine fungal-derived butyrolactone attenuates intestinal inflammation through MAPK/NF-κB and NLRP3 signaling pathway

  • Bioorg Chem. 2026 Jun 15:174:109730. doi: 10.1016/j.bioorg.2026.109730.
Ke-Shuang Tang 1,  Jing-Fei Lin 1,  Li-Jian Ding 2,  Fen-Er Chen 3
Affiliations

Affiliations

  • 1 Institute of Pharmaceutical Science and Technology, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, State Key Laboratory of Green Chemical Synthesis and Conversion, Zhejiang University of Technology, Hangzhou 310000, China.
  • 2 School of Pharmacy, Health Science Center, Ningbo University, Ningbo 315211, China. Electronic address: dinglijian@nbu.edu.cn.
  • 3 Institute of Pharmaceutical Science and Technology, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, State Key Laboratory of Green Chemical Synthesis and Conversion, Zhejiang University of Technology, Hangzhou 310000, China; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Fudan University, Shanghai 200433, China; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, China. Electronic address: rfchen@fudan.edu.cn.
PMID: 41806607 DOI: 10.1016/j.bioorg.2026.109730
Abstract

The structural complexity and potent biological activities of Marine natural products continue to attract considerable interest from chemists and biologists due to their unique biochemical mechanisms. In this study, we investigated the protective effects of a marine-sponge derived compound MBL-1 on intestinal inflammation. In vitro assays demonstrated that MBL-1 effectively reduced the production of key pro-inflammatory mediators, including NO, ROS, and cytokines such as IL-1β and IL-18. Mechanistic studies further revealed that these anti-inflammatory effects were mediated through inhibition of the MAPK/NF-κB and NLRP3 signaling pathway. Consistently, in vivo experiments showed that MBL-1 markedly attenuated histological damage and provided strong protection against DSS-induced colitis. Collectively, these findings highlight the potential of MBL-1 as a therapeutic candidate for ulcerative colitis, exerting its anti-inflammatory effects through the systemic modulation of the MAPK/NF-κB and NLRP3 signaling cascade.

Keywords

Intestinal inflammation; MAPK/NF-κB; MBL-1; Marine natural products; NLRP3 inflammasome.

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