2. Metabolic Enzyme/Protease Immunology/Inflammation MAPK/ERK Pathway NF-κB
  3. Endogenous Metabolite COX p38 MAPK NF-κB NOD-like Receptor (NLR) NO Synthase Reactive Oxygen Species (ROS) Interleukin Related
  4. MBL-1

MBL-1 是一种具有口服活性的抗炎剂。MBL-1 可从柳珊瑚来源的 Aspergillus sp. 的发酵液中分离。MBL-1 抑制 hCOX-2 蛋白的活性，其 IC50 为 5.77 μM。MBL-1 可通过抑制 MAPK/NF-κB 和 NLRP3 信号通路，减少 NO、ROS、IL-1β 和 IL-18 等关键促炎介质的产生。MBL-1 对 DSS 诱导的结肠炎具有保护作用。MBL-1 可用于溃疡性结肠炎的研究。

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MBL-1

MBL-1 Chemical Structure

CAS No. : 1815632-13-3

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MBL-1 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

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COX COX-1 COX-2 COX-3

查看 p38 MAPK 亚型特异性产品:

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p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 NOD-like Receptor (NLR) 亚型特异性产品:

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NLRP3 NLRP1 NOD1 NOD2

查看 NO Synthase 亚型特异性产品:

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nNOS iNOS eNOS

查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MBL-1 is an orally active anti-inflammatory agent. MBL-1 can be isolated from the fermentation broth of Aspergillus sp. derived from gorgonians. MBL-1 inhibits the activity of the hCOX-2 protein with an IC50 of 5.77 μM. MBL-1 reduces the production of key pro-inflammatory mediators such as NO, ROS, IL-1β and IL-18 by inhibiting the MAPK/NF-κB and NLRP3 signaling pathways. MBL-1 exerts a protective effect against DSS-induced colitis. MBL-1 can be used for the research of ulcerative colitis[1].

IC50 & Target[1]

Fungal Metabolite

 

hCOX-2

5.77 μM (IC50)

NLRP3

 

IL-1β

 

IL-18

 

体外研究
(In Vitro)

MBL-1 可强效抑制 hCOX-2 蛋白的活性，其 IC50 为 5.77 μM[1]。
MBL-1 (0.5-50 μM; 24 h) 在 RAW 264.7、J774A.1 和 MCF-7 细胞中，浓度高达 50 μM 时无细胞毒性[1]。
MBL-1 (2-30 μM; 1 h) 以剂量依赖方式抑制 LPS 刺激的 RAW 264.7 细胞中 NO 的生成[1]。
MBL-1 (2-30 μM; 1 h) 呈剂量依赖性抑制 LPS 刺激的 RAW 264.7 细胞中 ROS 的产生 [1]。
MBL-1 (2-30 μM; 1 h) 以剂量依赖方式抑制 LPS 刺激的 RAW 264.7 细胞中细胞因子 IL-6、IL-10 和 IL-1β 的产生[1]。
MBL-1 (2-30 μM) 剂量依赖性地抑制 RAW 264.7 细胞中 LPS 诱导的 p38、ERK 和 JNK 蛋白的磷酸化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MBL-1 相关抗体:
体内研究
(In Vivo)

MBL-1 (25-50 mg/kg；口服；每日 1 次) 对雄性 C57BL/6 J 小鼠中 DSS 诱导的急性结肠炎具有显著的剂量依赖性保护作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 J (male, 7 weeks old, DSS-induced colitis model)[1]
Dosage: 25 mg/kg; 50 mg/kg
Administration: p.o.; once daily; 7 days
Result: Mitigated DSS-induced body weight loss in a dose-dependent manner.
Attenuated progressive elevation of DAI scores in a dose-dependent manner.
Preserved colonic length in a dose-dependent manner, with 50 mg/kg dose resulting in a statistically significant increase compared to DSS-only controls.
Alleviated mucosal ulceration, preserved epithelial integrity, and reduced inflammatory cell infiltration; 50 mg/kg dose resulted in a statistically significant reduction in histological scores compared to DSS-only controls.
分子量

438.47

Formula

C25H26O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MBL-1 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MBL-11815632-13-3MBL1MBL 1Endogenous MetaboliteCOXp38 MAPKNF-κBNOD-like Receptor (NLR)NO SynthaseReactive Oxygen Species (ROS)Interleukin RelatedCyclooxygenaseNuclear factor-κBNuclear factor-kappaBNitric oxide synthasesNOSILCOX-2DSS-induced colitisMAPK/NF-κBIL-18NOAspergillus sp.RAW 264.7 cellsNLRP3 signaling pathwaysIL-1βROSInhibitorinhibitorinhibit

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