2. Cell Cycle/DNA Damage Cytoskeleton Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis
  3. Microtubule/Tubulin Reactive Oxygen Species (ROS) Apoptosis
  4. Microtubule-IN-15

Microtubule-IN-15 (Compound 10v) 是一种微管 (Microtubule) 抑制剂。Microtubule-IN-15 通过抑制微管蛋白聚合，破坏细胞有丝分裂纺锤体的形成，从而将细胞周期阻滞在 G2/M 期。Microtubule-IN-15 通过诱导线粒体膜电位下降和 ROS 爆发，促进肿瘤细胞凋亡 (apoptosis)。Microtubule-IN-15 可用于研究非小细胞肺癌和肝癌。

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Microtubule-IN-15

Microtubule-IN-15 Chemical Structure

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Microtubule-IN-15 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Microtubule-IN-15 (Compound 10v) is a microtubule inhibitor. Microtubule-IN-15 inhibits the polymerization of tubulin, thereby preventing the formation of the spindle apparatus in cell mitosis and blocking the cell cycle at the G2/M phase. Microtubule-IN-15 induces a decrease in mitochondrial membrane potential and a burst of reactive oxygen species (ROS), promoting tumor cell apoptosis. Microtubule-IN-15 can be used for the study of non-small cell lung cancer and liver cancer[1].

分子量

458.44

Formula

C26H19FN2O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Microtubule-IN-15 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Microtubule-IN-15Microtubule/TubulinReactive Oxygen Species (ROS)ApoptosisPhenylahistin derivativeMicrotubule inhibitionP53 signalingMitochondrial apoptosisPropargyl groupInhibitorinhibitorinhibit

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