2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Autophagy Apoptosis PI3K/Akt/mTOR
  3. Reactive Oxygen Species (ROS) Mitochondrial Metabolism Mitophagy Apoptosis PI3K Akt mTOR
  4. Molephantin

Molephantin 是一种可透过血脑屏障的抗胶质母细胞瘤剂。Molephantin 可诱导 ROS 生成，进而导致线粒体 (Mitochondrial) 损伤、线粒体自噬通量 (Mitophagy flux) 阻断和细胞凋亡 (Apoptosis)。Molephantin 能够抑制 PI3K/Akt/mTOR 信号通路。Molephantin 对胶质母细胞瘤具有抗肿瘤作用。

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Molephantin

Molephantin Chemical Structure

CAS No. : 50656-66-1

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规格 价格 是否有货 数量
1 mg ￥3840
1 - 2 周
5 mg 询价 1 - 2 周
10 mg 询价 1 - 2 周
50 mg   询价  
100 mg   询价  

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Molephantin 相关抗体

Top Publications Citing Use of Products

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Molephantin is a blood-brain barrier permeable anti-glioblastoma agent. Molephantin induces ROS generation, leading to mitochondrial damage, Mitophagy flux blockage and Apoptosis induction. Molephantin can suppress the PI3K/Akt/mTOR signaling pathway. Molephantin demonstrates antitumor effects against glioblastoma[1].

体外研究
(In Vitro)

Molephantin (72 h) 可抑制 U251 和 U87 胶质母细胞瘤细胞的增殖，其 IC50 值分别为 10.58 μM 和 22.64 μM[1]。
Molephantin (1-10 μM；6-24 h) 可抑制 U251 和 U87 胶质母细胞瘤细胞中的 PI3K/Akt/mTOR 信号通路[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molephantin 相关抗体:

Cell Cycle Analysis[1]

Cell Line: U251, U87
Concentration: 5-10 μM
Incubation Time: 24 h
Result: Arrested the cell cycle in the S phase, decreasing the proportion of cells in the G0/G1 phase and increasing the proportion in the S phase

Western Blot Analysis[1]

Cell Line: U251, U87
Concentration: 1-10 μM
Incubation Time: 6-24 h
Result: Decreased p-PI3K, p-Akt, and p-mTOR expression; reversed by NAC
体内研究
(In Vivo)

Molephantin (10-30 mg/kg；腹腔注射；每 2 天 1 次；21 天) 对携带有 U87 异种移植物的 BALB/c 裸鼠的胶质母细胞瘤生长具有显著抑制作用，且无明显毒性作用[1]。
Molephantin (30 mg/kg; i.p.) 可穿透 C57BL/6 小鼠的血脑屏障[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice (female, 7 weeks old)[1]
Dosage: 10 mg/kg; 30 mg/kg
Administration: i.p.; every two days; until day 21 post-administration
Result: Decreased tumor volume significantly; Reduced mean tumor weight to 0.17±0.05 g (10 mg/kg) and 0.12±0.07 g compared to control; Increased expression of apoptosis-related proteins (cleaved caspase 9, cleaved caspase 7, cleaved caspase 3, cleaved PARP) in tumor tissues; Increased Cleaved caspase 3-positive cells and TUNEL-positive cells; Decreased Ki67-positive cells.
Animal Model: C57BL/6 mice (male, 20–22 g)[1]
Dosage: 30 mg/kg
Administration: i.p.
Result: Detected a high chromatographic peak matching the Molephantin standard sample at 3.76 min in both plasma and brain tissue samples, confirming penetration through the blood-brain barrier.
分子量

346.37

Formula

C19H22O6
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Molephantin 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Molephantin50656-66-1Reactive Oxygen Species (ROS)Mitochondrial MetabolismMitophagyApoptosisPI3KAktmTORMitochondrial AutophagyPhosphoinositide 3-kinasePKBProtein kinase BMammalian target of Rapamycinmitophagy fluxcaspase cascadesmitochondrial dysfunctionPI3K/Akt/mTOR pathwayU251BALB/c nude miceU87mitochondrial apoptotic pathwayglioblastomablood-brain barrierInhibitorinhibitorinhibit

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